MASOT “Juvenile Toxicology” Webinar Attracts Over 450 Participants

On May 15, 2012, the Mid-Atlantic Regional Chapter (MASOT) held a very successful webinar on “Juvenile Toxicology.” MASOT President Janet Gould served as the webinar moderator and Robert M. Parker, Gregg D. Cappon, and Lynne Haber provided presentations that are briefly summarized below.  In addition to many webinar attendees from the United States, scientists from around the globe participated from Canada, Denmark, France, Germany, India, Japan, the Netherlands, and the United Kingdom. The webinar is posted on ToXchange and can be accessed by SOT members at MASOT Juvenile Toxicology Webinar.

Dr. Parker’s presentation focused on “Juvenile Toxicity Study Design and Methodology for Pharmaceuticals.” He provided toxicologists with a more detailed understanding of the technical and logistical factors involved in the performance of juvenile toxicity study. Juvenile toxicity designs range from general toxicity studies initiated in juvenile animals to highly complex study designs that include CNS, immunological, reproductive, and/or other target organ evaluations.

Dr. Cappon’s presentation addressed the “Application of Data Obtained from Juvenile Animal Toxicity Studies in the Pharmaceutical Industry.” A major factor in designing appropriate studies to provide the most meaningful information is an understanding of how data from juvenile animal toxicity studies can be used in risk assessment and risk management. He discussed the value of juvenile animal toxicity studies and how that information may influence future considerations on the appropriate strategy for nonclinical support for pediatric drug development.

Dr. Haber’s presentation examined the challenges of “Evaulating Children’s Risk for Industrial Chemicals: Approaches and Issues.” Unlike the situation for pharmaceuticals, where targeted testing to evaluate juvenile risk can be done on as needed basis, information on industrial chemicals is often more limited.  Consideration of children’s risk for industrial chemicals often must be done with the available data, without the possibility for additional testing. This analysis requires consideration of basic risk assessment principles and mode of action (MOA) information available for the chemical of interest.

The MASOT Program Committee (2011-2012) that developed this webinar includes Drs. Gould (Chair), Ray York, Jason Blum, Todd Davidson, George DeGeorge, John M. Mitchell, Gloria Post, Prathibha Rao, Kenneth Ruehl, Ravi Sitapara, Ric Stanulis, Karl Traul, Myra Weiner, and Arlene Weiss.

Support for this webinar was provided by SOT Headquarters. SOT members are encouraged to develop webinars and to submit proposals to facilitate their implementation. Additional information regarding this webinar support is available on the SOT Website.  To learn more about this SOT Regional Chapter, visit the MASOT website.

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