On June 22, US President Barack Obama signed the Frank R. Lautenberg Chemical Safety for the 21st Century Act, which reformed the 40-year-old Toxic Substances Control Act (TSCA). It passed the US House of Representatives by a 403 to 12 vote and the US Senate by a voice vote.
Each year, approximately a quarter of SOT members express a desire for the Society to engage in advocacy activities on behalf of toxicology. Aware of this interest, SOT Council continually monitors regulatory and political policy throughout the world to identify opportunities for engagement.
Toxicology transcends many boundaries, but while the science remains the same in disparate locations, local regulations and concerns have international impact and influence on approaches used in research.
Attrition of novel drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades-de-Pointes arrhythmia) remains a hurdle for drug discovery efforts.
Why should toxicologists and risk assessors care about epigenetics? According to Dana C. Dolinoy, PhD, University of Michigan School of Public Health, “many toxicologists may already be studying epigenetic phenomena — they just might not realize it.”