Historically, toxicity testing has relied upon the use of experimental animals, an approach that has a number of benefits. However, there are a number of drawbacks to conducting experimental animal tests. What are the novel animal alternatives being developed to bridge the gap?
Presenters at the read-across workshop demonstrated that read-across is a valuable technique; however, each described challenges yet to be overcome, including the incorporation and interpretation of ’omics data, improving reproducibility, and quantifying uncertainty in read-across predictions.
The current risk assessment process is in need of an update, and this workshop featured four experts who demonstrated how to incorporate systematic review, Adverse Outcome Pathways (AOP), and emerging risk methods into the safety assessment process.
SOT’s read-across workshop, “Read-Across: Building Scientific Confidence in the Development and Evaluation of Read-Across for Regulatory Purposes Using Tox21 Approaches,” was presented to a standing-room only crowd hungry for insight into perfecting the art of read-across.
Large amounts of in vitro data are being generated from high-throughput screening programs, and linking them to human exposure is paramount for their use in safety assessment.