Historically, toxicity testing has relied upon the use of experimental animals, an approach that has a number of benefits. However, there are a number of drawbacks to conducting experimental animal tests. What are the novel animal alternatives being developed to bridge the gap?
Presenters at the read-across workshop demonstrated that read-across is a valuable technique; however, each described challenges yet to be overcome, including the incorporation and interpretation of ’omics data, improving reproducibility, and quantifying uncertainty in read-across predictions.
While toxicologists may be trained to do excellent scientific work, they are rarely effectively trained in the subtle, but vital art of marketing. And in the digital age, effective toxicology communication is going to require marketing savvy and sophistication rarely learned at the bench.
Most toxicologists would agree that it is challenging to assess chemical exposure from consumer products. Freely available data sources that identify and quantify functional uses of chemicals are few and far between. Workshop presenters provided updates on some existing and in-development resources.
During a workshop session titled "Systems Toxicology: The Final Goal of the Emerging New Approach Methods," I laughed, learned, and literally cried, as Thomas Hartung discussed his personal experiences and work with "mini-brains."