Blogs

The August 2024 issue of Toxicological Sciences includes a Contemporary Review on the emerging relationships between PFAS and specific hepatic transporters. The issue also features a Forum article in which the author posits that “the dose disrupts the pathway” should replace “the dose makes the poison” and a Research Brief that explores the presence of microplastics in canine and human testes. Additionally, a #ToxSpotlight article discusses the effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of nonpneumonic endotoxemia while another #ToxSpotlight article explores the association between histopathologic effects and liver weight changes induced in mice and rats by chemical exposures.

• Contemporary Review: “Effects of PFAS on Human Liver Transporters: Implications for Health Outcomes” (free to read)
• Forum Article: “The Dose Disrupts the Pathway: Application of Paracelsus Principle to Mechanistic Toxicology”
• Research Brief: “Microplastic Presence in Dog and Human Testis and Its Potential Association with Sperm Count and Weights of Testis and Epididymis”
• ToxSpotlight Article: “Effects of Ozone Exposure on Lung Injury, Inflammation, and Oxidative Stress in a Murine Model of Nonpneumonic Endotoxemia” (free to read; topic category: environmental toxicology)
• ToxSpotlight Article: “The Association between Histopathologic Effects and Liver Weight Changes Induced in Mice and Rats by Chemical Exposures: An Analysis of the Data from Toxicity Reference Database (ToxRefDB)” (free to read; topic category: regulatory science, risk assessment, and decision making)

Other papers in the August 2024 issue (sorted by topic category) are:

Biotransformation, Toxicokinetics, and Pharmacokinetics

“Evaluating the Impact of Anatomical and Physiological Variability on Human Equivalent Doses Using PBPK Models”

Clinical and Translational Toxicology

“Effects of Combustible Cigarettes and Heated Tobacco Products on Immune Cell-Driven Inflammation in Chronic Obstructive Respiratory Diseases”

Computational Toxicology and Databases

“Cross Study Analyses of SEND Data: Toxicity Profile Classification” (open access)

Developmental and Reproductive Toxicology

“Single-Cell Insights into Mouse Testicular Toxicity under Peripubertal Exposure to Di(2-Ethylhexyl) Phthalate”

Environmental Toxicology

“PFAS and Their Association with the Increased Risk of Cardiovascular Disease in Postmenopausal Women” (free to read)

“Steatotic Liver Disease Induced by TCPOBOP-Activated Hepatic Constitutive Androstane Receptor: Primary and Secondary Gene Responses with Links to Disease Progression”

Molecular, Biochemical, and Systems Toxicology

“Regulation of Hepatic Xenosensor Function by HNF4alpha”

Neurotoxicology

“Ferrostatin-1 Mitigates Cellular Damage in a Ferroptosis-Like Environment in Caenorhabditis elegans”

Organ Specific Toxicology

“Drug-Induced Impairment of Mitochondrial Fatty Acid Oxidation and Steatosis: Assessment of Causal Relationship with 45 Pharmaceuticals”

“The Use of PD-1 Functional Knockout Rats to Study Idiosyncratic Adverse Reactions to Nevirapine”

Regulatory Science, Risk Assessment, and Decision Making

“Comparative Toxicological Assessment of 2 Bisphenols Using a Systems Approach: Evaluation of the Behavioral and Transcriptomic Responses of Danio rerio to Bisphenol A and Tetrabromobisphenol A” (open access)

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

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