SOT and the US Food and Drug Administration Center for Food Safety and Applied Nutrition (US FDA/CFSAN) cordially invite you to join us for our December 1 colloquium, “Arsenic and Children’s Health.” There is no charge for this webcast. The SOT FDA Colloquia are an update on toxicological science rather than a public forum for discussion of toxicology regulatory issues. The Co-Chairs of this session are Aaron Barchowsky, University of Pittsburgh, and Brenna Flannery, US FDA.
Arsenic is a naturally occurring element found in low concentrations in foods worldwide, including those commonly consumed by young children and pregnant women. Because arsenic occurs naturally, it is not possible to completely remove it from the food supply, which results in arsenic exposure. Arsenic exposure in utero and/or in childhood is associated with harmful effects, including adverse birth outcomes, developmental delay, decreased cognitive function, impaired lung function, and perturbations in the immune and cardiovascular systems, and leaves children at greater risk for future adult diseases. Therefore, for children’s health it is essential to understand the impact of arsenic exposure on child development.
This colloquium will present the latest science related to arsenic toxicity and children’s development from both toxicology and epidemiology perspectives, with specific focus on developmental arsenic exposure and the role of nutrition in arsenic toxicity. This colloquium will also explore the framework of ongoing risk assessments related to arsenic exposure and children’s health outcomes and discuss efforts related to arsenic mitigation in food to reduce children’s arsenic exposure. The session will end with a roundtable discussion for further exploration of the topics.
Schedule (All times are Eastern US, UTC -5)
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9:00 AM–9:15 AM
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Welcome and Overview
Conrad Choiniere, PhD, Office of Analytics and Outreach Office Director, US FDA/CFSAN, College Park, MD
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9:15 AM–9:20 AM
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Speaker Introductions
Aaron Barchowsky, PhD, University of Pittsburgh, Pittsburgh, PA
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9:20 AM–10:00 AM
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Current Understanding of Mechanisms Underlying Arsenic-Induced Developmental Toxicity
Rebecca Fry, PhD, University of North Carolina at Chapel Hill, Chapel Hill, NC
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10:00 AM–10:40 AM
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Nutritional Manipulation of One-Carbon Metabolism: Effects on Arsenic Methylation and Toxicity
Mary Gamble, PhD, Columbia University, New York, NY
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10:40 AM–10:50 AM
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Break
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10:50 AM–11:30 AM
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Systematic Review Framework and Dose-Response Methods for Identifying Reference Doses for Inorganic Arsenic
Allen Davis, MSPH, US EPA/CPHEA, Washington DC
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11:30 AM–12:10 PM
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Arsenic Mitigation in Foods and Ingredients
Cheryl Callen, Nestle USA, Arlington, VA
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12:10 PM–1:00 PM
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Summary
Brenna Flannery, PhD, US FDA, College Park, MD
Roundtable Discussion
Moderators: Co-Chairs
Discussion: All speakers
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