SOT FDA Colloquium May 4: Toxicogenomics and Its Relevance to Support Hazard Assessment

By Udayan Apte posted 04-28-2022 13:57


SOT and the US Food and Drug Administration Center for Food Safety and Applied Nutrition (US FDA/CFSAN) cordially invite you to join us for our May 4 colloquium, “Toxicogenomics and Its Relevance to Support Hazard Assessment.” There is no charge for this webcast. The SOT FDA Colloquia are an update on toxicological science rather than a public forum for discussion of toxicology regulatory issues. The Co-Chairs of this session are Stephen Edwards, RTI International, and Xiugong Gao, US FDA.

Toxicogenomics uses genomic technologies to gain mechanistic understanding of biological effects induced by exposure to chemicals and may provide more sensitive biomarkers for the prediction and assessment of their toxicity, thus contributing significantly to toxicology. With recent technological innovations such as next generation sequencing (NGS), toxicogenomics now provides an unprecedented opportunity for improved, animal-free risk assessment of chemicals. Nonetheless, challenges remain in many aspects of toxicogenomics to meet regulatory needs. This colloquium will present the state-of-the-science in toxicogenomics and its relevance to support hazard assessment of chemicals. Recent technological innovations in toxicogenomics will be covered, and case studies of toxicogenomics application in risk assessment and toxicity prediction of chemicals related to food and cosmetics will be highlighted. The colloquium also will discuss current challenges facing regulatory application and provide perspectives on future directions of toxicogenomics.

Schedule (All times are Eastern US, UTC -4)

9:00 AM–9:10 AM
Welcome from FDA
Steven M. Musser, Deputy Director of Scientific Operations, US FDA/CFSAN
Welcome from SOT
Michael Aschner, SOT President
9:10 AM–9:15 AM
Overview and Speaker Introductions
Stephen Edwards, Colloquium Co-Chair, RTI International
9:15 AM–10:00 AM
Overview of Toxicogenomics and Its Contribution to Toxicological Science
Carole L. Yauk, University of Ottawa/Health Canada, Ottawa, ON, Canada
10:00 AM–10:40 AM
High-Throughput Transcriptomics for Chemical Bioactivity Screening and Tiered Hazard Evaluation
Joshua A. Harrill, US EPA, Research Triangle Park, NC
10:40 AM–10:50 AM
10:50 AM–11:30 AM
Toxicogenomics to Support Hazard Assessment
Russell Thomas, US EPA, Research Triangle Park, NC
11:30 AM–12:10 PM
Application of Toxicogenomics in Toxicity Assessment of Chemicals in Food and Cosmetics
Jorge Naciff, Procter & Gamble Company, Mason, OH
12:10 PM–1:00 PM
Roundtable Discussion
Moderators: Co-Chairs
All speakers