The series of SOT FDA Food Safety Colloquia continues with the March 27 session “Can Alternatives Inform Risk Assessments of Mixtures in Food?” Chaired by A. Wallace Hayes and co-chaired by Suzanne Fitzpatrick, this event will explore hazard identification related to multiple substances rather than the usual approach of assessing individual substances in singular food commodities. Mixtures that humans encounter in foods can be variable and constantly changing and defining them presents a challenge. Models could be used independently and in an integrated manner to assess health impacts. This colloquium will examine whether new testing approaches such as in vitro, in silico, and non-mammalian in vivo models could be used to assess the potential health impacts of exposure to chemical mixtures in food.
Registration for the webcast is open. The colloquium is from 8:30 am–12:50 pm ET (GMT-4) March 27. Webcast participants are encouraged to submit questions for discussion during the roundtable that follows the presentations. Registration to participate onsite at Wiley Auditorium at the US FDA in College Park, MD, is closed except for US federal employees.
Presentations include:
- Why a New Approach is Needed, A. Wallace Hayes, University of South Florida College of Public Health, Tampa, FL, and Institute for Integrative Toxicology, Michigan State University, East Lansing, MI
- Can High Thru-put Assays/Tox 21 Inform the Risk Assessment?, Michael J. Devito, National Toxicology Program, Research Triangle Park, NC
- Proposed In Silico/In Vitro Approach for Botanical Mixtures, Catherine Mahony, Procter & Gamble Technical Centres Ltd, Surrey, UK
- Non-Mammalian In Vivo Models: C. elegans as a Model System to Inform Hazard Identification, Piper Reid Hunt, US FDA, Laurel, MD
- Extrapolating New Approaches into a Tiered Approach to Mixtures Risk Assessment, Mike Dourson, Toxicology Excellence for Risk Assessment, Cincinnati, OH
The SOT FDA Colloquia on Emerging Toxicological Science: Challenges in Food and Ingredient Safety present scientific training that is high quality, cutting-edge, future-oriented toxicological science for US FDA employees and are open to the public at no cost. However, the colloquia are not a public forum for discussion of toxicology regulatory issues.
Recordings and slides from the previous colloquia are available free via the SOT FDA Colloquia website, including the fall session, October 24, 2017, “Analysis of In Vitro to In Vivo Concordance Studies for Food Safety Assessment in Humans.”