SOT 2018 Toxicological Sciences Paper of the Year Featured in March Editorial

The current issue of Toxicological Sciences (April 2018, Vol. 162, Issue 2) is now online. This issue features an Editorial by Editor-in-Chief Gary Miller on the 2018 Toxicological Sciences Paper of the Year: Assessing Fibrogenesis Using 3D-Printed Liver Tissues.  An excerpt of the Editorial is below.


 Left to right: SOT Councilor Tao Wang, Edward L. LeCluyse, Leah M. Norona, and ToxSci Editor-in-Chief Gary Miller

“At the 57th Annual Meeting of the Society of Toxicology in San Antonio, TX, the Board of Publications awarded the Paper of the Year to Norona et al. for their paper “Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues.” The authors were Leah M. Norona, Deborah G. Nguyen, David A. Gerber, Sharon C. Presnell, and Edward L. LeCluyse. Each year the Society of Toxicology Board of Publications recognizes the outstanding research published in Toxicological Sciences by selecting the paper deemed to be the most influential during the past year. Papers published in the print edition from July to June of the preceding year are eligible. The members of the Board of Publications review the papers published during that time and, after extensive deliberation, select the recipient.

The use of 3D printers has revolutionized many aspects of manufacturing. Plastics, resins, and metallic-based materials can be used to build objects via printing technology. These systems allow one to use computer-aided design packages to make small specialty parts that historically would have required a very labor- and skill-intensive machinist. The approach took off in industry sectors where specialty parts need to be made to exacting specifications. The medical sector has also been able to take advantage of this approach for the construction of small medical devices and parts. In the paper by Norona et al. (2016) we get to see what happens when the above technology is combined with biology." (more)

The mission of Toxicological Sciences is to publish the most influential science in toxicology and four articles are noted in Editor's Highlights prepared by ToxSci Associate Editors. These highlights include HTS for T4 to T3, Alison H. Harrill; Glutathione Restoration and Acetaminophen, Ronald N. Hines; Zebrafish and Drug Discovery, Robert L. Tanguay; and 2D versus 3D for DILI, Nathan J. Cherrington.

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