During the SOT 58th Annual Meeting and ToxExpo Opening Plenary Lecture, “Robust Assembly of Human Tissues for Disease Modeling and Discovery,” Dr. William L. Murphy explained how technologies he is developing can be applied to toxicological screening.
The approach explained involved major steps, such as to expand stem cells to differentiate into early precursor cells. These precursor cells would undergo morphogenesis to form organoid systems. These organoid systems can be used as a human disease model. He emphasized that the surrounding environment of these cells is an important factor to decide how these precursor cells would differentiate.
Synthetic alternatives can be used as alternatives to naturally derived extracellular matrix screening applications. In a study comparing synthetic hydrogel with Matrigel, the former was found to have a higher Z score, indicating its excellence over Matrigel. In collaboration with Stem Pharm, self-organized patient derived human brain organoids are being developed for predictive screening purposes. With the help of machine learning tools, 9/10 blindfolded identifications were correctly done for potential carcinogens.
Overall, this lecture did an impressive job of explaining technologies developed and their application to toxicology through academia-industry collaboration.
This blog was prepared by an SOT Reporter. SOT Reporters are SOT members who volunteer to write about sessions and events they attend during the SOT Annual Meeting and ToxExpo. If you are interested in participating in the SOT Reporter program in the future, please email Giuliana Macaluso.
Editor’s Note: The recording of the SOT 58th Annual Meeting and ToxExpo Opening Plenary Lecture, “Robust Assembly of Human Tissues for Disease Modeling and Discovery,” is available on the SOT website.