May 2019 ToxSci: Exploring Gene Editing and Highlights from the Issue

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In his penultimate “From the Editor’s Desk” remarks, which appear in Volume 169, Issue 1, May 2019, of Toxicological Sciences, Editor-in-Chief Gary W. Miller—with acknowledgment to Lesa Aylward—discusses gene editing techniques employing clustered regularly interspaced short palindromic repeats, or CRISPR:

“Gene editing technologies including zinc finger nuclease and transcription activator-like effector nucleases (TALENs) have been in use for a decade or more. However, the development of gene editing methods based on CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9) is nothing short of revolutionary in the biological sciences. Although CRISPR-based gene editing techniques are at the forefront of many areas of biomedical science, adoption and integration of these techniques into the broader functional genomics landscape in toxicology is just beginning. A recent National Academy of Sciences workshop explored the current and potential applications of these technologies in toxicology. In this issue, Sobh and colleagues report a CRISPR screen approach to identify novel genes involved in the toxicity of acetaldehyde. This is just another example of why I encourage you to look inside ToxSci for the most influential research in the field of toxicology.”

This month’s four Editor’s Highlights exemplify the leading toxicological research that defines ToxSci:

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