Vishal S. Vaidya is awarded the Society of Toxicology (SOT) 2014 Leading Edge in Basic Science Award. Dr. Vaidya received his PhD in Toxicology from the University of Louisiana in 2003. As an Assistant Professor at Harvard Medical School, he leads the Systems Toxicology Program within the Harvard Program in Therapeutic Sciences and directs the Laboratory of Kidney Toxicology and Regeneration at Brigham and Women’s Hospital.
His work in the past five years will change the way textbooks are written and science is conducted with respect to deploying biomarkers for monitoring kidney damage. Dr. Vaidya challenged the fundamental mechanism of kidney toxicity regarding injury assessment and developed, evaluated, and validated novel tools for biomarker detection applicable from bench to bedside, comparing the remarkably consistent sensitivity and specificity of urinary Kim-1 over several other potential biomarkers in a large number of collaborative studies. These studies are going to have a very significant impact on the way we monitor for kidney toxicity in drug development and in the clinic.
The outcome of his work in collaboration with the Predictive Safety Testing Consortium is such that Kim-1 is now accepted by US, European, and Japanese regulatory agencies as a suitable marker of kidney injury to be used in drug discovery. Currently, he is exploring the role of fibrinogen and related molecules and miRNA’s as possible mechanistic markers of kidney injury in humans.
In 2011, Dr. Vaidya was awarded the Outstanding New Environmental Scientist Award by the National Institute of Environmental Health Sciences (NIEHS) and in 2013, he was chosen to be one of six North American scientists to receive the Innovation in Regulatory Science Award from Burroughs Wellcome Fund. Dr. Vaidya has been a member of the Society since 1999. During this time he has served as a member of the Career Resources and Development (CRAD) Committee (2006–2009) and Continuing Education Committee (2011–2014). He also has served as a Councilor to the SOT Northeast Regional Chapter.
The Society is pleased to present Dr. Vaidya with the 2014 Leading Edge in Basic Science Award.