The next Scientific Liaison Coalition (SLC) webinar series is on Systematic Review and is developed by the Evidence-Based Toxicology Collaboration (EBTC) at the Johns Hopkins University Bloomberg School of Public Health on the initiative of the Society for Risk Analysis and with the support of the Society of Toxicology (SOT) and other members of the Scientific Liaison Coalition. The series, "Theory and Practical Applications of Systematic Review to Support Regulatory Decision-making for Evidence-based Risk Assessment," will include two webinars that will be held on September 11 (Introduction to SR and Their Application in Preclinical Research and Chemical Risk Assessment at EFSA) and November 27 (Practical Application of SR in the US), both from 11:00 am-12:30 pm ET USA. The SOT is among the founding members of this coalition. This webinar series is open only to members of the partnering societies of the SLC listed on the SLC website, and you must register via the links above or on the SLC website in advance to attend.
The use of systematic review (SR) and evidence-based methodologies in toxicology and risk assessment have evolved from theory to practice. This webinar series will provide an overview of the history of SR, describe the general principles of SR, challenges encountered in adopting the methodologies from medicine to toxicology, and present case studies of its use in regulatory decision-making in different domains. The presentations will focus on efforts specifically associated with risk-based practices, such as development of health-based benchmarks (e.g., acceptable daily intakes, reference doses, etc.), rather than characterization of potential hazard (e.g., likelihood to be a hazard to humans for a given health outcome). The presenters will provide examples of how tools and frameworks initially developed to facilitate the use of SR in the field of medicine are being adapted to apply to toxicological research questions and to inform decisions.
Moreover, the presentations will describe how the regulatory practitioners have addressed the challenges of toxicological data search, selection, synthesis, and analysis relative to that of medicine. For example, they will consider challenges in evaluating exposures vs. controlled clinical trial interventions, diverse data obtained in a variety of experimental animal species, in vitro and computational studies vs. randomized controlled trials in a single species (humans), as well as evaluation of mixtures vs. pure chemical substances. Beyond evaluation of individual studies, the webinars will demonstrate new approaches to integrate data from different evidence streams in the context of risk. It is anticipated that this series will provide practical information for toxicologists and risk assessors to facilitate an understanding of how systematic review is being utilized in support of risk-based chemical assessments. Notably, speakers will also highlight how SR adds rigor, comprehensiveness, and transparency for the assessment of chemicals to inform decisions.
About EBTC: EBTC at Johns Hopkins Bloomberg School of Public Health is an international collaboration of academic, government, non-government, and industry leaders united in bringing evidence-based methods and principles into toxicology. EBTC’s mission is to bring together the international toxicology community to facilitate use of evidence-based toxicology to inform regulatory, environmental, and public health decisions. EBTC’s vision is that evidence-based toxicology is the standard used to ensure public health, a healthy environment, and a sustainable future. To learn more, visit the EBTC website.
The mission of the SLC is “improving the ability of societies to partner with other domestic and international organizations with the goal of advancing science to improve human and environmental health” by efforts to:
- Strengthen partnerships among health science organizations to increase awareness of toxicology and related sciences on human health.
- Enhance cooperation among societies with the goal of accomplishing tasks benefitting human health and disease prevention through joint and shared activities.
For more information about the SLC, please contact Marcia Lawson.