The recognition of hemangiosarcoma in plastics workers led to the worldwide recognition of vinyl chloride (VC) as a carcinogen in the 1970s. Work to understand the health effects of VC has continued since, including how VC interacts with underlying fatty liver diseases.
Beginning in the 1990s, cognitive enhancers in the form of cholinesterase inhibitors have become the mainstay of drug therapy for Alzheimer’s disease. Dr. Farinde explores the various therapeutics used to treat Alzheimer’s disease and their therapeutic targets.
In the 1950s, the use of thalidomide by pregnant women led to more than 10,000 children being born with birth defects worldwide and resulted in the adoption of systemic testing of pharmaceutical products for developmental toxicity prior to marketing.
As shared in this SOT Tox Impact Statement, toxicologists played a crucial role in determining the inhalation risks of the flavoring agent diacetyl (2,3-butanedione), which caused irreversible obstructive lung disease in occupational settings before its toxicity was known.
This SOT Tox Impact Statement explores the major role toxicologists have played in identifying the health risks—such as effects on the brain, heart, kidney, lung, and immune system—associated with exposure to methylmercury.