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Trying to Improve Predictions of Adverse Cardiovascular Event Potential Early in Drug Development

The “Cardiovascular Effects Are Still Causing Late Attrition of Novel Therapeutics: Developing Solutions to Detect and Avoid Cardiovascular Toxicity in the Clinic” Scientific Session during the 2018 Annual Meeting and ToxExpo provided a comprehensive overview of the various tools available to...

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Cutting-Edge Research on Mitochondrial Toxicity

Subcellular toxic effects are getting more and more attention as the field of toxicology delves further into subcellular mechanisms of toxicity. As my own research has recently focused on the effects of 2D manganese dioxide nanomaterials on mitochondria, I was excited to see several sessions at...

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Difficulties with Animal Models and Alternative Approaches: Moving Toward New Forms of Testing

Putting Lessons Learned from SOT Scientific Sessions into Practice Before I proceed with my report on the 2017 Workshop Session "Safety or Prediction? What is the Future of Regulatory Toxicity Testing," it would be appropriate to state my Conflict of Interest (COI) and bias, which is a...

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Mitochondria As the Central Target of Environmental Contaminants, Pharmaceutical Agents, & Toxicants

Mitochondria (MT) are organelles commonly referred to as the powerhouse of the cell due to the fact that their main function is to generate ATP to provide energy for cellular functions. Mutations that cause DNA instability often lead to a wide range of MT diseases, which was the topic of the ...

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Fatty Liver Disease Linked to Chemical Exposures

This morning, presenters discussed how some environmental chemicals may lead to steatosis—fatty liver disease—during the session “ Does This Chemical Make My Liver Look Fat? (Environmental Exposures and Steatosis) .” The session co-chairs, Charlene A. McQueen, PhD, ATS, US EPA, and Nathan J....