The recording and slides are available now for “The Evolving Science in Developmental Immunology and Immunotoxicity” that was presented to an audience of 184 individuals on May 4, 2023. This event was the most recent in the SOT FDA Colloquia on Emerging Toxicological Science: Challenges in Food and Ingredient Safety series. Each colloquium in this series is approximately four hours in duration.
The most recent colloquium addressed age-related susceptibility of the immune system to potentially toxic compounds. The immature immune system is especially vulnerable to environmental insults, and there is increasing evidence that the microbiome affects immune system development. This colloquium focused on the use of animal studies to assess the risk of chemicals to the developing immune system and challenges associated with using animal data to support hazard identification and risk evaluation.
Leigh Ann Burns Naas, Magnolia Toxicology Consulting LLC, and Patrick Crittenden, US FDA Center for Food Safety and Applied Nutrition, co-chaired the colloquium.
Presentations included:
- “The Evolution of the Discipline of Developmental Immunotoxicology”
Leigh Ann Burns Naas, PhD, DABT, ATS, ERT, Magnolia Toxicology Consulting, LLC
- “Comparative Developmental Immunology and Implications for Testing and Data Interpretation”
Hollie Skaggs, PhD, Horizon Therapeutics
- “The Role of the Metagenome and Microbiome during Pregnancy and Lactation on the Risk of Immune-Related Disease”
Kjersti M. Aagaard, MD, PhD, FACOG, Baylor College of Medicine
- “Prenatal Immunity Represents a Functionally Distinct Hematopoietic Lineage”
Eliver Ghosn, PhD, Emory University School of Medicine
- “Paving the Road toward the Development and Acceptance of Alternative (In Vitro) Methods to Assess Developmental Immunotoxicity”
Fenna Sille, PhD, Johns Hopkins University Bloomberg School of Public Health
The recording includes the roundtable discussion that followed the presentations.
Materials from the other 28 colloquia in the SOT FDA series also can be accessed via the colloquium web page. An extensive range of topics is available, including recent sessions on alternative approaches for process-formed constituents in food, toxicogenomics, arsenic and children’s health, toxicology of nanoparticles, and new plant-based foods.
Plans are underway for two new colloquia in the next year on sweetener alternatives (December 2023) and CBD toxicology (second quarter 2024).
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