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The “SOT Program Spotlight” series is aimed at increasing awareness of how SOT programs and activities are focused on addressing and/or supporting the Society’s guiding principles of (1) serving the needs of the scientific discipline and our members to enhance human, animal, and environmental health; (2) life-long learning and intellectual scientific stimulation; (3) diversity of representation in all activities of the Society; and (4) integrity. Graduate students are a valued and valuable part of the SOT membership, and the Society recognizes the importance of career development opportunities during this stage. To this end, SOT offers many opportunities for ...
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SOT is a partner in a NIH-funded mentoring and training project to increase the number of students from underrepresented groups on the pathway to careers in toxicology and the biomedical sciences. The Toxicology Mentoring Skills Development Training program ( ToxMSDT ), based at University of California Davis (UCD), is a multi-institutional collaborative national training program. Recruitment is now underway for the 2021–2022 cohort of 25 undergraduates, with applications due May 1. Mentor applications will be available soon and are due June 1, 2021. Please pass this invitation to apply to potential student and mentor participants. Student eligibility criteria ...
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The year 2020 marked the spread of a global pandemic that took the world by surprise and halted life as we knew it. It also emphasized the dangers posed by air-borne pathogens and their potential to cause massive havoc. For a respiratory toxicologist, these were interesting times! Scientific breakthrough in the form of a vaccine or therapy was the need of the hour while researchers working in respiratory/ infection biology took center stage. Though times were challenging, they paved way for interesting and innovative research, and the SOT 60th Annual Meeting and ToxExpo featured some of the best research in toxicology from across the globe this year. Being ...
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Dr. Rebecca Fry, a professor at the University of North Carolina at Chapel Hill, was awarded the 2021 SOT Translational Impact Award for her translational research on developmental toxicants and public health. Her Award Lecture during the 2021 SOT Annual Meeting and ToxExpo, “The Placenta: A Recorder and Transducer of Environmental Toxics,” described how her research has utilized different models, such as cells, mice, and human cohorts, to study the interplay between environmental toxicants, the placenta, and children’s health. The placenta is well known for being responsible for nutrient transfer and waste exchange between mother and fetus during pregnancy. ...
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The threshold of toxicological concern (TTC) is a science-based concept that categorizes chemicals with low-level exposures. No appreciable human health risk for a lifetime of 70 years is expected for exposure values below the TTC. The US Food and Drug Administration (US FDA) Threshold of Regulation for indirect food additives was the scientific basis for the TTC concept. This approach has been accepted by various global regulatory agencies for assessment of impurities, cosmetic ingredients, chemicals food packaging materials, etc. With the ever-changing landscape of risk assessment, the TTC concept has evolved, with a diverse range of applications. The developments ...
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SOT is committed to embracing diversity and optimizing inclusion. To kick off the Virtual 2021 SOT Annual Meeting and ToxExpo, 47 SOT members from 42 different institutions representing all sectors of toxicology (academia, government, and industry) came together on Friday, March 12, to consider the role of diversity, equity, and inclusion (DEI) in undergraduate education. The workshop was organized and facilitated by the FUTURE Committee. Before the workshop, participants were asked to identify their goals for the workshop, what they perceived to be central barriers to DEI in toxicology education, and the role that SOT could play to address them, as well as how ...
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The April 2021 issue of the Society’s official journal, Toxicological Sciences , opens with a special editorial by SOT Past Presidents Jay I. Goodman and Norbert E. Kaminski honoring SOT Past President and respected toxicologist Jerry B. Hook, who passed away this year. In addition to this editorial, the issue includes another feature in the form of a Forum article: “ FutureTox IV Workshop Summary: Predictive Toxicology for Healthy Children .” Also published in the latest edition of ToxSci are two Tox Spotlights: “ Elucidation of the Effects of Bisphenol A and Structural Analogs on Germ and Steroidogenic Cells Using Single Cell High-Content Imaging ...
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Dear Colleagues, On behalf of the Scientific Program Committee (SPC), I invite you to submit your proposal for ICT 2022 , which will be held in Maastricht, September 18–22, 2022. The International Congress of Toxicology is a joined meeting of IUTOX and EUROTOX organized in collaboration with the Netherlands Society of Toxicology. The theme of the 2022 ICT, “ Uniting in Toxicology,” reflects our desire to address topics dealing with different disciplines. Working together, these disciplines, with their diverse perspectives, contribute to promoting and encouraging the use of new and innovative techniques and strategies that will continue to reduce ...
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SOT is thrilled to announce its multi-year partnership with the Alan Alda Center for Communicating Science at Stony Brook University . This partnership will bring the Alan Alda Center’s unique science communication training, which is built on the foundations of improvisational theater, to the SOT membership. Through this training, SOT members will enhance their ability to effectively communicate and engage with the public, with policymakers, and with fellow scientists. To achieve this, SOT has partnered with the Alan Alda Center to provide its core online training program, “The Essentials,” to selected SOT members. Two training sessions will be offered per ...
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Why do some toxicologists make inadequate propositions or assumptions while interpreting quantitative data? And why do these same mistakes occur repeatedly? It all comes down to violation of three fundamental quantitative principles. This was presented by Dr. Wout Slob, the recipient of the 2019 EUROTOX Bo Holmstedt Memorial Award. The Bo Holmstedt Memorial Award is presented every year during the EUROTOX Congress to scientists who have made outstanding research contributions to the science of drug or chemical toxicology. This lecture also is presented during SOT Annual Meeting the following year. Unfortunately, the 2020 SOT Annual Meeting was canceled because ...
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The placenta is a very unique organ, responsible for ensuring the healthy development of fetuses early in life. However, we still know very little about this organ despite its importance. During the 2021 SOT Annual Meeting and ToxExpo Symposium Session titled “Environmental Influences on Placental Origins of Development,” several researchers highlighted how they are studying the placenta and its role in environmental exposure and developmental toxicity. Dr. Thad Schug from the National Institute of Environmental Health Sciences started the session with an introduction on the placenta. The placenta is the intermediary between mother and fetus throughout pregnancy ...
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EUROTOX President Heather M. Wallace has officially announced that the 2021 EUROTOX Congress, originally scheduled to take place in Copenhagen, Denmark, will be held virtually. According to Dr. Wallace, the decision was made in light of “the remaining uncertainty around travel and vaccination status.” The virtual event will take place from September 26 to October 1 and will feature both recorded and live sessions. An exhibition and industry-sponsored sessions will still be part of the event. As a result of the change in the meeting format, the deadline to submit an abstract for the congress has been extended to April 30, 2021, and registration rates will ...
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More than 4,000 attendees joined the Society during the first-ever all-virtual SOT Annual Meeting and ToxExpo, March 12–26, 2021. The Virtual 2021 Annual Meeting offered a venue for sharing the latest science in toxicology, through Continuing Education (CE) courses, Scientific Sessions, Poster Sessions, and more. SOT held CE courses every Friday during the Annual Meeting, for a total of 14 courses and 1,400 participants across courses. More than 65 Featured and Scientific Sessions also served as vehicles of scientific exchange during the meeting. More than a dozen Featured Sessions offered discussion and debate around leading topics in toxicology, including ...
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The Virtual 2021 Annual Meeting has now entered the on-demand phase, and registrants will be able to view all content through May 31. During the on-demand phase, the Scientific Program Committee (SPC) is preparing for the 2022 Annual Meeting in San Diego, California! The SPC will host its annual webinar designed to illuminate the process by which proposals for Scientific Sessions are reviewed as well as the criteria for evaluation. The SPC values the input received from the membership—in particular, the SOT Specialty Sections, Special Interest Groups, and Committees—with respect to the Annual Meeting program. Therefore, please mark your calendar for Wednesday, ...
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Alternative splicing events can lead to differential responses to xenobiotics because of the modified synthesis of proteins. In other words, how each new protein variant is able to contribute to metabolism and disease progression is a roll of the dice. In the Workshop Session “Revising Biology: Alternative Splicing in Toxicology” during the SOT 60th Annual Meeting and ToxExpo, Drs. Annalora, Wright, and Cardoso presented their research on the mechanisms by which alternative splicing alters wild-type protein functions. Among other things, this research may allow for splicing variants to be used as novel biomarkers of exposures and predictors of prognosis. ...
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Uncertainty factors were developed in the 1980s by the US Environmental Protection Agency (US EPA) to derive a margin of safety of a chemical when the data are extrapolated from animals to humans. As we move toward animal-free testing with the application of new approach methods (NAMs), animal testing is being slowly replaced by in vitro studies using human cells and organ-on-a-chip models. Are uncertainty factors required when human cells are used? This was debated during the Roundtable Session at the Virtual SOT 60th Annual Meeting and ToxExpo titled “The Future of Uncertainty Factors with In Vitro Studies Using Human Cells.” Dr. Suzanne Fitzpatrick ...
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“All substances are poisons; there is none which is not a poison. The right dose differentiates a poison.” –Paracelsus (AD 1493–1541) The first step in designing a successful nonclinical toxicity study is the selection of appropriate dose levels. Risk assessment of a drug or chemical involves the use of toxicokinetic data to characterize the exposure through a better understanding of the dose-response relationship. However, there are significant challenges in interpreting these dose-response relationships, and this was addressed in a Symposium Session during Virtual SOT 60th Annual Meeting and ToxExpo titled “Opportunities and Challenges in Utilization of ...
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The Federation of American Societies for Experimental Biology (FASEB) has announced its 2021 Science Research Conferences . According to the FASEB website , these conferences “enable scientists, faculty, postdoctoral fellows, and graduate students to discuss scientific advances and share cutting-edge research through lectures, poster sessions, and informal discussions online.” With events beginning in May and continuing into October, the 2021 Science Research Conferences include several events of interest to the toxicology community. SOT members are encouraged to explore the list of conferences, which are taking place largely virtually, with continual evaluation ...
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As part of the Virtual 2021 SOT Annual Meeting and ToxExpo, SOT partnered with WebsEdge to produce SOT TV —a compilation of scientific interviews, company profiles, and SOT-focused features. All SOT TV content is available now for viewing on YouTube for attendees and non-attendees alike. Segments range from 2 to 10 minutes and can be watched in any sequence. Enjoy these interesting and informative films. Episode One — View the full episode > Importance of Strong Science Communication—a feature about the SOT Strategic Priority regarding science communication and the new partnership between SOT and the Alan Alda Center for Communicating ...
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In an era of rapidly advancing technology, the learning curve required to incorporate new techniques into your research can be intimidating. The terminology alone can be a barrier to entry as you work through new protocols and read up on the available literature. Even as someone who uses single cell RNAseq and ATAC-seq in my research, it can be difficult to follow along with talks introducing new single cell technology. The Workshop Session “The Methodological Road toward Single Cell High-Throughput Transcriptomics” during the Virtual SOT Annual Meeting introduced new technology and described advantages of emerging single cell systems. With my research in the ...
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