Blogs

The February 2024 issue of Toxicological Sciences includes a Contemporary Review that will discuss how CRISPR insertion and deletion mutations are susceptible to compensation by transcriptional adaptation, alternative splicing, and rescue by maternally derived gene products. Additionally, #ToxSpotlight articles will discuss how cadmium exposure following early-life respiratory syncytial virus infection has a significant impact on subsequent inflammatory response and lung metabolism and how environmental factors interact with genetics in the development of autoimmunity and autoimmune disease.

• Editor’s Note: “Thank You, ToxSci 2023 Reviewers” (free to read)
• Contemporary Review: “Mechanistic Toxicology in Light of Genetic Compensation” (free to read)
• ToxSpotlight Article: “Metabolic Reprograming and Increased Inflammation by Cadmium Exposure Following Early-Life Respiratory Syncytial Virus Infection: The Involvement of Protein S-Palmitoylation” (free to read; topic category: environmental toxicology)
• ToxSpotlight Article: “Naturally Occurring Autoimmune Disease in (NZB × NZW) F1 Mice Is Correlated with Suppression of MZ B-Cell Development Due to Aberrant B-Cell Receptor (BCR) Signaling, Which Is Exacerbated by Exposure to Inorganic Mercury” (free to read; topic category: immunotoxicology)

Other papers in the February 2024 issue (sorted by topic category) are:

Computational Toxicology and Databases
“Rat Deconvolution as Knowledge Miner for Immune Cell Trafficking from Toxicogenomics Databases” (open access)

Developmental and Reproductive Toxicology
“Fetoplacental Disposition and Toxicity of Cadmium in Mice Lacking the Bcrp Transporter”

“Mono-(2-ethylhexyl) Phthalate Reversibly Disrupts the Blood-Testis Barrier in Pubertal Rats” (open access)

Emerging Technologies, Methods, and Models
“Extracellular Vesicles Altered by a Per- and Polyfluoroalkyl Substance Mixture: In Vitro Dose-Dependent Release, Chemical Content, and Microrna Signatures Involved in Liver Health”

Endocrine Toxicology
“Toxicological Mechanisms and Potencies of Organophosphate Esters in KGN Human Ovarian Granulosa Cells as Revealed by High-Throughput Transcriptomics”

Exposure Sciences
“Investigating the Replacement of Carboxylates with Carboxamides to Modulate the Safety and Efficacy of Platinum(II) Thioether Cyanide Scavengers” (open access)

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

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