Blogs

The March 2024 issue of Toxicological Sciences includes two editorials that discuss mentoring the next generation of ToxSci authors and the Toxicological Sciences Paper of the Year. A forum article explains a biological questions-based approach to human chemical hazard and drug safety assessment while two #ToxSpotlight articles reveal how the yes-associated protein, a known liver cancer inducer, has different molecular interactions in mice versus humans and what 10 years of using key characteristics of human carcinogens in IARC Monographs has taught us.

• Editorial: “Mentoring the Next Generation of ToxSci Authors—I Spy ToxSci” (free to read)
• Editorial: “2022–2023 Toxicological Sciences: Paper of the Year” (free to read)
• Forum: “Enabling Novel Paradigms: A Biological Questions-Based Approach to Human Chemical Hazard and Drug Safety Assessment” (open access)
• ToxSpotlight Article: “Interaction with YAP Underlies the Species Differences between Humans and Rodents in CAR-Dependent Hepatocyte Proliferation” (free to read; topic category: molecular, biochemical, and systems toxicology)
• ToxSpotlight Article: “Ten Years of Using Key Characteristics of Human Carcinogens to Organize and Evaluate Mechanistic Evidence in IARC Monographs on the Identification of Carcinogenic Hazards to Humans: Patterns and Associations” (free to read; topic category: regulatory science, risk assessment, and decision making)

Other papers in the March 2024 issue (sorted by topic category) are:

Biomarkers

“A Network-Based Transcriptomic Landscape of HepG2 Cells Uncovering Causal Gene-Cytotoxicity Interactions Underlying Drug-Induced Liver Injury” (open access)

Biotransformation, Toxicokinetics, and Pharmacokinetics

“Disposition of Glycolic Acid into the Embryo Following Oral Administration of Ethylene Glycol during Placentation in the Rat and Rabbit”

Carcinogenesis

“Formation of Hepatocyte Cytoplasmic Inclusions and their Contribution to Methylcarbamate-Induced Hepatocarcinogenesis in F344 Rats”

Clinical and Translational Toxicology

“Hepatocyte miR-21-5p-Deficiency Alleviates APAP-Induced Liver Injury by Inducing PPARγ and Autophagy”

Developmental and Reproductive Toxicology

“Long-Lasting Developmental Effects in Rat Offspring after Maternal Exposure to Acetamiprid in the Drinking Water 5tgb Gestation”

“Responses of Peritubular Macrophages and the Testis Transcriptome Profiles of Peripubertal and Adult Rodents Exposed to an Acute Dose of MEHP” (open access)

Emerging Technologies, Methods, and Models

“Zoledronic Acid and Ibandronate-Induced Nephrotoxicity in 2D and 3D Proximal Tubule Cells Derived from Human and Rat”

Neurotoxicology

“Ammonium Perchlorate: Serum Dosimetry, Neurotoxicity, and Resilience of the Neonatal Rat Thyroid System”

“Bypassing the Brain Barriers: Upregulation of Serum miR-495 and miR-543-3p Reflects Thyroid-Mediated Developmental Neurotoxicity in the Rat”

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

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