Blogs

The April 2024 issue of Toxicological Sciences includes a Contemporary Review that discusses surgical smoke and its components, effects, and mitigation. It also features an In-Depth Review about the emerging role of hypoxia and environmental factors in inflammatory bowel disease, while a Forum article argues that evidence evaluated by EFSA does not support lowering the tolerable daily intake of bisphenol A. Additionally, #ToxSpotlight articles describe how obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis and review cardiotoxicity assessments of bisphenol chemicals and estradiol using human-induced pluripotent stem cell–derived cardiomyocytes.

• Contemporary Review: “Surgical Smoke and Its Components, Effects, and Mitigation: A Contemporary Review” (free to read)
• In-Depth Review: “The Emerging Role of Hypoxia and Environmental Factors in Inflammatory Bowel Disease” (free to read)
• Forum: “Evidence Evaluated by European Food Safety Authority Does Not Support Lowering the Temporary Tolerable Daily Intake for Bisphenol A” (open access)
• ToxSpotlight Article: “Obesogenic Polystyrene Microplastic Exposures Disrupt the Gut-Liver-Adipose Axis” (free to read; topic category: environmental toxicology)
• ToxSpotlight Article: “Comparative Cardiotoxicity Assessment of Bisphenol Chemicals and Estradiol Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes” (free to read; topic category: organ specific toxicology)

Other papers in the April 2024 issue (sorted by topic category) are:

Computational Toxicology and Databases

“A Systems Toxicology Approach for Identification of Disruptions in Cholesterol Homeostasis after Aggregated Exposure to Mixtures of Perfluorinated Compounds in Humans”

Genetic and Epigenetic Toxicology

“Circ0087385 Promotes DNA Damage in Benzo(a)pyrene-Induced Lung Cancer Development by Upregulating CYP1A1”

Immunotoxicology

“The Development and Characterization of a CRISPR/Cas9-Mediated PD-1 Functional Knockout Rat as a Tool to Study Idiosyncratic Drug Reactions”

Neurotoxicology

“Developmental Exposure to Pesticides That Disrupt Retinoic Acid Signaling Causes Persistent Retinoid and Behavioral Dysfunction in Zebrafish”

“Developmental Toxicity of Pyriproxyfen Induces Changes in the Ultrastructure of Neural Cells and in the Process of Skull Ossification”

Organ Specific Toxicology

“Exploring the Effects of Topoisomerase II Inhibitor XK469 on Anthracycline Cardiotoxicity and DNA Damage” (open access)

“Chronic Arsenic Exposure Affects Stromal Cells and Signaling in the Small Intestine in a Sex-Specific Manner”

“Preclinical Cardiovascular Safety Assessment of Pharmacology-Toxicology Relationship for a Set of Novel Kinase Inhibitors”

“Spatial Analysis of Renal Acetaminophen Metabolism and Its Modulation by 4-Methylpyrazole with DESI Mass Spectrometry Imaging”

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