Upcoming July Biological Modeling Specialty Section Webinar


By Jeffery Gearhart posted 07-13-2017 10:15


The Society of Toxicology (SOT) Component Groups (Regional Chapters, Special Interest Groups, and Specialty Sections) host many webinars throughout the year. Webinars are an effective distance-learning method intended to impart scientific knowledge to members of their group as well as the SOT membership at large. These webinars are just one of the many benefits of SOT membership.

The upcoming Biological Modeling Specialty Section webinar is listed below.

Biological Modeling Specialty Section (BMSS)

Topic: Performance Assessment and Translation of Individual or Population Physiologically Based Pharmacokinetic Models
Date and Time: Friday, July 21, 2017, 11:00 am–12:00 pm Eastern Time
Event address and registration for attendees

Many physiologically based pharmacokinetic (PBPK) models for environmental chemicals, drugs, and nanoparticles have been developed for various applications using acslX, but acslX has been rendered sunset since November 2015. Alternative modeling tools and tutorials are needed for future PBPK applications. In this webinar, Dr. Zhoumeng Lin will introduce our recent publication describing the performance assessment and translation of PBPK models for oxytetracycline and gold nanoparticles from acslX to several other modeling tools, including Berkeley Madonna, MATLAB, and R language.

First, he will briefly introduce the method of converting the models from acslX to other programs. A detailed tutorial is provided in the Supplementary Material of the article. He then will present the comparisons of model simulation results from different software packages. A tentative procedure of checking the performance of a PBPK model between different programming platforms will be proposed. Next, the advantages and disadvantages of each software package with respect to implementation of PBPK models in risk assessment will be discussed. Additionally, preliminary results of comparing the performance of a population PBPK model for penicillin G between Berkeley Madonna and R language will be presented. Lastly, he will share his plan for future work and his opinions about the future direction in this field. 

Registration is required.