SOT and the US Food and Drug Administration Center for Food Safety and Applied Nutrition (US FDA CFSAN) cordially invite you to join us for our December 7, 2023, colloquium, “The Evolving Research Landscape of Low- and No-Calorie Sweeteners.” There is no charge for this webcast. The SOT FDA Colloquia are an update on toxicological science rather than a public forum for discussion of toxicology regulatory issues. The co-chairs of this session are Anne Macgregor-Das, PhD, US FDA CFSAN, and Daniele Wikoff, PhD, ToxStrategies LLC.
Many different types of sweeteners used in the US are utilized broadly across food products. By law, these must be safe for consumption. Companies are responsible for ensuring the safety of ingredients and rely on standard approaches to substantiate safety. This involves utilization of standard toxicological experimental studies investigating the potential for adverse effects following acute and repeated-dose exposure and assessing potential risk associated with use of the sweetener as intended by the ingredient use. More recently, the scientific community has begun to explore additional health outcomes and to assess novel aspects of exposure/outcome relationships via observational studies in human populations.
This colloquium will survey modern aspects of low- and no-calorie sweetener research, including the emerging literature pertaining to sweeteners and their effects on the microbiome, and the potential impact of these changes on human health and consideration of data types other than traditional toxicology testing in animals, including epidemiological and mechanistic data. The recent re-evaluation of aspartame will serve as a case study for how these emerging studies are being considered by risk assessors. The colloquium will conclude with a panel discussion on the key issues and knowledge gaps identified by the speakers and questions from participants.
Schedule (US EST, UTC -5)
9:00 AM–9:10 AM
Welcome from US FDA
Kristi Muldoon Jacobs, PhD, Acting Director US FDA CFSAN Office of Food Additive Safety, Rockville, MD
9:10 AM–9:50 AM
An Introduction to Low- and No-Calorie Sweetener Uses in Foods and Beverages in the US
Corey Scott, PhD, Cargill, Plymouth, MN
9:50 AM–10:30 AM
Low- and No-Calorie Sweeteners and Metabolic Health: A Review of the Evidence from Acute Metabolic and Endocrine Responses to Long-Term Clinical Outcomes
John Sievenpiper, MD, PhD, FRCPC, University of Toronto and St. Michael’s Hospital, Toronto, Ontario, Canada
10:30 AM–10:40 AM
10:40 AM–11:20 AM
Mechanistic and Epidemiological Studies and Their Role in the Safety Assessment of Low- and No-Calorie Sweeteners
Daniele Wikoff, PhD, ToxStrategies LLC, Asheville, NC
11:20 AM–12:00 Noon
Aspartame as a Case Study in Re-evaluation of Sweetener Safety by the Joint FAO/WHO Expert Committee on Food Additives
Diane Benford, PhD, 2023 Chair of the Joint FAO/WHO Expert Committee on Food Additives, Leighton Buzzard, United Kingdom
12:00 Noon–1:00 PM
Moderator: Anne Macgregor-Das, PhD, US FDA CFSAN
Previous Colloquia Recordings
The video and speaker slides for “The Evolving Science in Developmental Immunology and Immunotoxicity,” the most recent colloquium, are available at the colloquium website, as are materials for the other 28 previous sessions.