Blogs

The April 2023 issue of Toxicological Sciences includes a contemporary review that examines glyphosate toxicity from an in vivo, in vitro, and epidemiological perspective and ToxSpotlight articles on how developmental exposure to an AHR-binding chemical can diminish methylation contribute to durable changes in antiviral CD8+ cytotoxic T lymphocytes functions later in life and what mechanisms underly hydrogen sulfide–induced acute toxicity and death. The issue also features an in-depth review on programmed or regulated cell death, focusing on apoptosis, pyroptosis, necroptosis, and ferroptosis, and pathological cell death, including cuproptosis, as well as an in-depth review that discusses a framework for applying new approach methodologies to one health toxicological risk assessments.

• Contemporary Review: “Glyphosate Toxicity: In Vivo, In Vitro, and Epidemiological Evidence” (free to read)
• In-Depth Review: “Die Hard: Cell Death Mechanisms and Their Implications in Nanotoxicology” (Open Access)
• In-Depth Review: “A Pragmatic Framework for the Application of New Approach Methodologies in One Health Toxicological Risk Assessment” (Open Access)
• ToxSpotlight Article: “Postnatal Administration of S-adenosylmethionine Restores Developmental AHR Activation–Induced Deficits in CD8+ T-cell Function during Influenza A Virus Infection” (free to read; topic category: immunotoxicology)
• ToxSpotlight Article: “Investigations into Hydrogen Sulfide–Induced Suppression of Neuronal Activity In Vivo and Calcium Dysregulation In Vitro” (free to read; topic category: neurotoxicology)

Other papers in the April 2023 issue (sorted by topic category) are:

Developmental And Reproductive Toxicology

• “Epigenetic Programming of TBX2/CX43 Mediates Lower Sperm Quality in Male Offspring Induced by Prenatal Dexamethasone Exposure”

Emerging Technologies, Methods, and Models

• “A Model Template Approach for Rapid Evaluation and Application of Physiologically Based Pharmacokinetic Models: Extension to Volatile Organic Compounds”

Environmental Toxicology

• “Fine Particulate Matter (PM2.5)–Induced Pulmonary Oxidative Stress Contributes to Changes in the Plasma Lipidome and Liver Transcriptome in Mice”

Exposure Sciences

• “Excretion of Polybrominated Diphenyl Ethers and AhR Activation in Breastmilk among Firefighters” (Open Access)

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

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