Blogs

The July 2023 issue of Toxicological Sciences includes a Systematic Review that examines autophagy biomarkers and the effects of cadmium on autophagy and apoptosis, while a Forum article reviews the use of mechanistic pathways, such as adverse outcome pathways and mode of action, in hazard and risk assessment. There also are ToxSpotlight articles on the in vivo use of the degradation tag system for target protein degradation and the role of PPARγ in ozone-induced dyslipidemia and aberrant lung function in mice.

• Systematic Review: “Cadmium-Induced Stress: A Close Look at the Relationship between Autophagy and Apoptosis”
• Forum Article: “The Need for Good Practice in the Application of Mechanistic Constructs in Hazard and Risk Assessment”
• ToxSpotlight Article: “Use of the dTAG System In Vivo to Degrade CDK2 and CDK5 in Adult Mice and Explore Potential Safety Liabilities” (open access; topic category: emerging technologies, methods, and models)
• ToxSpotlight Article: “Role of PPARγ in Dyslipidemia and Altered Pulmonary Functioning in Mice Following Ozone Exposure” (free to read; topic category: organ specific toxicology)

Other papers in the July 2023 issue (sorted by topic category) are:

Developmental and Reproductive Toxicology

“Maternal Pre-conceptional Glyphosate Exposure Impacts the Offspring Hepatic and Ovarian Proteome” (open access)

Emerging Technologies, Methods, and Models

“Per- and Polyfluoroalkyl Substances (PFAS) in Mixtures Show Additive Effects on Transcriptomic Points of Departure in Human Liver Spheroids” (open access)

Endocrine Toxicology Exposure Sciences

“Fetal and Neonatal Dioxin Exposure Causes Sex-Specific Metabolic Alterations in Mice” (open access)

Exposure Sciences

“Genetic Background in the Rat Affects Endocrine and Metabolic Outcomes of Bisphenol F Exposure”

Immunotoxicology

“Quantifying the Impact of PFOA Exposure on B-Cell Development and Antibody Production” (open access)

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

#Communique:ScienceNews
#ToxicologicalSciences