Blogs

The August 2023 issue of Toxicological Sciences includes a Systematic Review that examines whether PFAS exposure during breastfeeding causes adverse effects, while an In-Depth Review highlights insights into PFAS toxicokinetics, toxicity and apical adverse health effects, and potential modes of action that were discovered by using a zebrafish model. There also are #ToxSpotlight articles on the evaluation of an in vitro rat airway epithelial model compared to a human one for acute inhalation toxicity testing and refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels.

• Systematic Review: “Public Health Evaluation of PFAS Exposures and Breastfeeding: A Systematic Literature Review”
• In-Depth Review: “Review of the Zebrafish as a Model to Investigate Per- and Polyfluoroalkyl Substance Toxicity” (open access; topic category: in-depth review)
• ToxSpotlight Article: “Evaluation of In Vitro Rat and Human Airway Epithelial Models for Acute Inhalation Toxicity Testing” (free to read; topic category: emerging technologies, methods, and models)
• ToxSpotlight Article: “Refining Risk Estimates for Lead in Drinking Water Based on the Impact of Genetics and Diet on Blood Lead Levels Using the Collaborative Cross Mouse Population” (free to read; topic category: exposure sciences)

Other papers in the August 2023 issue (sorted by topic category) are:

Developmental and Reproductive Toxicology

“A CRISPR-Cas9 Mutation in sox9b Long Intergenic Noncoding RNA (slincR) Affects Zebrafish Development, Behavior, and Regeneration”

“ATF6 Is a Critical Regulator of Cadmium-Mediated Apoptosis in Spermatocytes”

Endocrine Toxicology

“Coupling the H295R with Erα and AR U2OS CALUX Assays Enables Simultaneous Testing for Estrogenic, Anti-Androgenic, and Steroidogenic Modalities” (open access)

Environmental Toxicology

“Maternal PBDE Exposure Disrupts Gut Microbiome and Promotes Hepatic Proinflammatory Signaling in Humanized PXR-Transgenic Mouse Offspring over Time”

Organ Specific Toxicology

“Mechanistic Investigation of Liver Injury Induced by BMS-932481, an Experimental Ɣ-Secretase Modulator”

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

#ToxicologicalSciences
#Communique:ScienceNews