Blogs

The September 2023 issue of Toxicological Sciences includes ToxSpotlight articles on how exposure to a specific phthalate may tamper with the ovarian insulin-like growth factor 1 system, affecting the reproductive health of female mice, and on a new high-throughput assay that may provide an in vitro solution to studying structural cardiotoxicity. The issue also features an In-Depth Review that examines the taxonomic domain of applicability in a cross-species adverse outcome pathway network for thyroid hormone system disruption.

• In-Depth Review: “Cross-Species Applicability of an Adverse Outcome Pathway Network for Thyroid Hormone System Disruption” (topic category: in-depth review)
• ToxSpotlight Article: “Human-Relevant Exposure to di-n-butyl Phthalate Tampers with the Ovarian Insulin-Like Growth Factor 1 System and Disrupts Folliculogenesis in Young Adult Mice” (free to read; topic category: developmental and reproductive toxicology)
• ToxSpotlight Article: “CardioMotion: Identification of Functional and Structural Cardiotoxic Liabilities in Small Molecules through Brightfield Kinetic Imaging” (free to read; topic category: emerging technologies, methods, and models)

Other papers in the September 2023 issue (sorted by topic category) are:

Carcinogenesis

“Role of Nrf2 in 1,2-Dichloropropane-Induced Cell Proliferation and DNA Damage in the Mouse Liver”

Developmental and Reproductive Toxicology

“Prenatal Exposure to Diethylstilbestrol Has Long-Lasting, Transgenerational Impacts on Fertility and Reproductive Development” (open access)

Environmental Toxicology

“IL33-Mediated NPM1 Promotes Fibroblast-to-Myofibroblast Transition via ERK/AP-1 Signaling in Silica-Induced Pulmonary Fibrosis”

Genetic and Epigenetic Toxicology

“CircRNA hsa_circ_0000043 Acts as a miR-4492 Sponge to Promote Lung Cancer Progression via BDNF and STAT3 Expression Regulation in Anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-Transformed 16HBE Cells”

Neurotoxicology

“Machine Learning Reveals Common Transcriptomic Signatures across Rat Brain and Placenta Following Developmental Organophosphate Ester Exposure”

Organ Specific Toxicology

“Lead Exposure Suppresses the Wnt3a/β-catenin Signaling to Increase the Quiescence of Hematopoietic Stem Cells via Reducing the Expression of CD70 on Bone Marrow-Resident Macrophages”

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

#Communique:SOTNews
#ToxicologicalSciences