Blogs

The October 2023 issue of Toxicological Sciences includes ToxSpotlight articles that explain how the Comparative Toxicogenomics Database explores the way environmental chemicals interact with genes and influence biological processes to affect human health and how γH2AX and Ki-67 may be able to classify genotoxic hepatocarcinogens (GHs) from non-GH chemicals. The issue also features a ToxPoint article that discusses what the authors view as inherent flaws in the data and study of Ramazzini Institute carcinogenicity studies of aspartame.

• ToxPoint: “Is Statistical Re-evaluation of Hemolymphoreticular Neoplasms from Aspartame Studies Valid?” (open access)
• ToxSpotlight Article: “CTD Tetramers: A New Online Tool That Computationally Links Curated Chemicals, Genes, Phenotypes, and Diseases to Inform Molecular Mechanisms for Environmental Health” (free to read; topic category: computational toxicology and databases)
• ToxSpotlight Article: “Early Detection of Genotoxic Hepatocarcinogens in Rats Using γH2AX and Ki-67: Prediction by Machine Learning” (free to read; topic category: emerging technologies, methods, and models)

Other papers in the October 2023 issue (sorted by topic category) are:

Computational Toxicology and Databases

“Comparison of In Silico, In Vitro, and In Vivo Toxicity Benchmarks Suggests a Role for ToxCast Data in Ecological Hazard Assessment”

Developmental and Reproductive Toxicology

“Antiepileptic Drugs Are Endocrine Disruptors for the Human Fetal Testis Ex Vivo”

“Exosome-Shuttled miR-126 Mediates Ethanol-Induced Disruption of Neural Crest Cell-Placode Cell Interaction by Targeting SDF1”

Emerging Technologies, Methods, and Models

“Human Cell–Based In Vitro Systems to Assess Respiratory Toxicity: A Case Study Using Silanes” (open access)

Environmental Toxicology

“Arsenic Disrupts Extracellular Vesicle-Mediated Signaling in Regenerating Myofibers”

Neurotoxicology

“Deletion of IL-1β Exacerbates Acrylamide-Induced Neurotoxicity in Mice”

“Tbx2 Knockdown Alleviated Sevoflurane-Induced Cognitive Disorder and Neuron Damages in Aged Rats via Suppressing Oxidative Stress and Ferroptosis”

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

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