ToxSci March 2024 Issue Available

By Laurie Haws posted 03-07-2024 13:30


The March 2024 issue of Toxicological Sciences includes two editorials that discuss mentoring the next generation of ToxSci authors and the Toxicological Sciences Paper of the Year. A forum article explains a biological questions-based approach to human chemical hazard and drug safety assessment while two #ToxSpotlight articles reveal how the yes-associated protein, a known liver cancer inducer, has different molecular interactions in mice versus humans and what 10 years of using key characteristics of human carcinogens in IARC Monographs has taught us.

Other papers in the March 2024 issue (sorted by topic category) are:


A Network-Based Transcriptomic Landscape of HepG2 Cells Uncovering Causal Gene-Cytotoxicity Interactions Underlying Drug-Induced Liver Injury(open access)

Biotransformation, Toxicokinetics, and Pharmacokinetics

Disposition of Glycolic Acid into the Embryo Following Oral Administration of Ethylene Glycol during Placentation in the Rat and Rabbit


Formation of Hepatocyte Cytoplasmic Inclusions and their Contribution to Methylcarbamate-Induced Hepatocarcinogenesis in F344 Rats

Clinical and Translational Toxicology

Hepatocyte miR-21-5p-Deficiency Alleviates APAP-Induced Liver Injury by Inducing PPARγ and Autophagy

Developmental and Reproductive Toxicology

Long-Lasting Developmental Effects in Rat Offspring after Maternal Exposure to Acetamiprid in the Drinking Water 5tgb Gestation

Responses of Peritubular Macrophages and the Testis Transcriptome Profiles of Peripubertal and Adult Rodents Exposed to an Acute Dose of MEHP(open access)

Emerging Technologies, Methods, and Models

Zoledronic Acid and Ibandronate-Induced Nephrotoxicity in 2D and 3D Proximal Tubule Cells Derived from Human and Rat


Ammonium Perchlorate: Serum Dosimetry, Neurotoxicity, and Resilience of the Neonatal Rat Thyroid System

Bypassing the Brain Barriers: Upregulation of Serum miR-495 and miR-543-3p Reflects Thyroid-Mediated Developmental Neurotoxicity in the Rat

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