In a letter addressed to the Chair and Ranking Member of the Senate Committee on Environment and Public Works and the Chair and Ranking Member of the Subcommittee on Superfund, Toxics and Environmental Health, 20 Past Presidents of the Society of Toxicology (SOT) reported they agree that S. 1009, The Chemical Safety Improvement Act (CSIA), would create a systematic and transparent framework under which the US Environmental Protection Agency would assess the safety of chemicals in commerce. S. 1009 is a proposed approach to reforming the Toxic Substances Control Act (TSCA). The letter goes on to say that "The CSIA promotes use of best available science, fosters tiered testing and assessment, encourages development and application of advanced toxicological methods to reduce or replace lab animal studies where appropriate, and requires integration of exposure information to improve the understanding of the safety of chemicals under conditions of intended use." The signatories go on to point out that as core emphases of toxicology, "these provisions of the CSIA form a solid foundation from which improvements to TSCA can be built." In closing, SOT's former leaders graciously offer to assist Congress in ensuring that "TSCA improvements fully reflect the principles and best practices of toxicology." In addition to the 20 Past President who signed the letter, Past Presidents Joseph F. Borzelleca and Linda S. Birnbaum expressed their support for the letter. Dr. Birnbaum noted that her views do not represent the views of the National Institute of Environmental Health Sciences, National Institutes of Health, or the United States. Read the letter in its entirety.