Join us on Sunday, March 13, 2016, for a Continuing Education Morning Course! Keep your knowledge up-to-date in your field or learn new techniques with presentations by top experts.
To see more information and to register for a course, visit the SOT Annual Meeting website.
Morning (AM) Courses include:
AM02 (Advanced) Advancing the Detection, Imaging, and Pitfalls in Monitoring Oxidative Stress in Health and Disease—Attendees will leave the course with an enhanced understanding that measurement of oxidative stress in vivo requires innovative, unconventional methodologies in combination with advanced technologies and often a multidisciplinary approach.
AM03 (Basic) Adverse Outcome Pathway (AOP) Development and Evaluation—The value of AOP development will be demonstrated via examples from the European Food Safety Agency and by considering integrated approaches to testing and assessment using the skin sensitization AOP, which was endorsed by the OECD in 2012.
AM04 (Basic) Contribution of Mitochondria to Drug-Induced Organ Toxicities—This course will provide an in-depth overview of mitochondrial biology and different mechanisms in which drugs can affect mitochondrial function. Particular emphasis is given to mitochondrial toxicity causing heart, liver, and kidney injury. In addition, we will describe novel high-throughput in vitro screening technologies in isolated mitochondria and cell models to elucidate potential mitochondrial toxicity.
AM05 (Advanced) Discovery and Validation of miRNA Biomarkers Bridging Preclinical and Clinical Toxicity: Lessons Learned from Hepatotoxicity—The goal of this course is to provide investigators with an overview of the techniques and strategies necessary to progress a biomarker from the discovery stage to practical use in animal and human xenobiotic safety assessment. Well studied biomarkers, such as miR-122, will be used as case studies to demonstrate the path from nonclinical discovery to a validated clinical biomarker.
AM06 (Basic) Embryology and Developmental Toxicity Testing—This course will focus on preclinical species and will begin by providing an overview of mammalian development, including important gestational milestones, comparative interspecies timelines, and definitions of critical periods in development. Next, we will discuss how this information has factored into the design of traditional preclinical studies. The presentation will conclude with a brief introduction to normal variability in some organ systems.
AM07 (Advanced) Next-Generation Sequencing in Toxicogenomics—The discussed topics include, but are not limited to, applicability of respective NGS platforms for analyzing mutational spectra, gene expression modifications, epigenomic alterations induced by toxicants in a range of biological systems, a comparison of performance with standardized qPCR/microarray techniques, present use cases, and highlighted future challenges.