Dear SOT Members:
The United Kingdom National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs) and the Medicines and Healthcare Products Regulatory Authority (MHRA) have convened an expert working group to generate an evidence base that will inform the use of human tissue in testing the safety of potential new medicines, with an initial focus on safety pharmacology studies.
This survey is being distributed widely to the safety assessment community to better understand the extent of human tissue use for assessing safety pharmacology and what the barriers might be to wider adoption of these approaches to generate data to support clinical trial applications.
We ask that you consider completing the survey to help provide the evidence base to move these aspirations forward. The deadline for responding to this consultation is September 27, 2013.
If you would like to discuss this further, please contact Anthony Holmes who is leading this initiative.
Thank you in advance.
Sincerely,
Lois D. Lehman-McKeeman, PhD, ATS
2013–2014 President
Society of Toxicology