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Warren Casey Receives 2016 SOT Enhancement of Animal Welfare Award

By Raul Suarez posted 01-25-2016 13:49

  

Warren Casey, PhD, DABT, currently serves as the Director of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and the Executive Director to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). There he provides leadership and coordinates work within the US federal government to promote scientific validation and regulatory acceptance of safety testing methods and approaches that more accurately assess the safety and health hazards of chemicals, while reducing, refining, or replacing the use of animals.

2016 Enhancement of Animal Welfare_Award - Warren Casey-2.jpg

Warren Casey Receives 2016 SOT Enhancement of Animal Welfare Award

At the epicenter of validating non-animal methods into regulatory use in the US and abroad, he and his team have introduced a more systematic review of traditional animal studies as a point of comparison for the evaluation of new approaches, as shown most recently for the uterotrophic assay. As announced in the Federal Register, this effort enabled the US Environmental Protection Agency now to consider this approach for the Endocrine Disruptor Screening Program where results from high throughput screening assays now are being accepted as alternatives to low throughput, animal-based Tier 1 tests. Currently undertaking a similar approach with the Hershberger assay and a computational model based on HTS assays that map the androgen receptor pathway is yet another example of Dr. Casey’s efforts to develop scientifically sound methods to validate alternative testing strategies to be considered by regulatory agencies.

A few additional examples of his body of work include the development of integrated approaches to testing and assessment for skin sensitization submitted to the Organization for Economic Co-operation and Development (OECD) as case studies, service on international validation management groups for novel in vitro tests (e.g., eye irritation), analysis in support of waiving the requirement for dermal acute toxicity testing, and a new project to work with developmental toxicology experts to develop a list of reference chemicals to evaluate stem cell assays.

Dr. Casey received his PhD in Microbiology, Department of Microbiology, from North Carolina State University in Raleigh, North Carolina. He is an active member of the Society and has presented at SOT symposia and webinars as well as sessions held during the SOT Annual Meetings.

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