Because of the attention that has been given to the tools and technologies associated with toxicology testing in the 21st Century, the Society hosted two major events in the Washington, DC area to address the challenges and opportunities associated with the explosion of 21st Century toxicity testing technologies and tools. A Congressional luncheon briefing entitled, “FutureTox: Consideration of 21st Century Toxicology and Risk Assessment Practices in Legislation and Regulation” featured a panel discussion about the tools and technologies and the challenges facing regulators and legislators as they work to find improved, science-informed hazard prediction and risk assessment methodologies they can implement. SOT also hosted a two-day seminar entitled, “Building the Road for 21st Century Toxicology and Risk Assessment Practices.” The event focused on four major themes starting with a review and discussion of the various strategies being considered. The two-day event was organized as a workshop to encourage active dialog among attendees about the technically complex and interdisciplinary landscape of new technologies available to toxicology.