During the Symposium Session “Accessing Acute Health Risk: Potential Application of Next-Generation Toxicological Tools” at the SOT 58th Annual Meeting and ToxExpo, Dr. Tiffany Bredfeldt explained exposure assessment and risk management using ambient air monitoring data in Texas. This project combined advanced lab techniques such as mobile monitoring, auto-GC (gas chromatography), and data analyses to evaluate ethane levels where oil was extracted.
Dr. Lorenz Rhomberg mentioned approaches to using in vitro data in exposure-duration extrapolation using pharmacokinetic and -dynamic knowledge about chemicals of interest. He emphasized time-course shape of the chemical, that slower process dominates time-course shape, the importance of the pharmacodynamic model, and the use of the theoretical model for structure and direct thinking.
Dr. David Dorman focused on application of modern toxicology approaches for predicting acute toxicity. He showed how different methods, such as using nontesting approaches, biological assays, and tools using various databases, can help us to prioritize chemicals to study and reduce our health risk.
Dr. Lyle Burgoon informed how to predict chemical affinity and extrapolate safe acute exposure levels with examples of opioid class drugs such as fentanyl and carfentanyl. The take-home message of his presentation was the importance of the domain of applicability one is considering for their model. During his energized and entertaining lecture, he kept the audience awake and engaged.
Dr. George Woodall summarized how to bring next-generation toxicological tools into acute health risk assessments. After mentioning key definitions in risk assessments, he briefed on roadmaps of approaches to access acute health risk.
This session was helpful for novices and experts in the field of acute health risk assessment.
This blog was prepared by an SOT Reporter. SOT Reporters are SOT members who volunteer to write about sessions and events they attend during the SOT Annual Meeting and ToxExpo. If you are interested in participating in the SOT Reporter program in the future, please email Giuliana Macaluso.