This National Institutes of Health (NIH) Request for Information (RFI) invites comments on the inclusion of clinical research across the lifespan and announces a workshop to be held on this topic. In response to scientific need and a congressional mandate in the 21st Century Cures Act (P.L. 114-255), the NIH is convening a workshop of experts on the appropriate inclusion of pediatric and older populations in research studies involving human subjects. The workshop will be held on June 1–2, 2017, on the NIH campus to bring together experts in clinical research to discuss augmenting participation of these populations in NIH-funded clinical studies. There also will be a videocast of the workshop so that any interested individuals may view the presentations and reports. Moreover, the NIH is publishing this Notice to solicit input from the wider scientific community and welcomes comments from the public concerning inclusion in research. For additional information and guidance on submitting comments, please refer to the RFI notice.