Submitted by Bette Meek, Jay Zhao, and John C. Lipscomb, 2014 Continuing Education Presenters
PBPK Modeling, Mode of Action Analysis, Benchmark Dose Modeling, and Chemical Specific Adjustment Factors…What is Risk Assessment coming to? What’s wrong with the way we used to do it? Are you finding yourself stuck in the same old rut? Tired of getting criticized for not working in the new millennium? Sunday morning, March 23, join us in Phoenix to see what these advances are all about.
SOT’s Continuing Education (CE) Course (AM06), Methodologies in Human Health Risk Assessment, brings together internationally recognized leaders in their respective areas to distill the advantages, data requirements, and methods for these approaches to modern risk assessment. The unifying theme for these lectures is that chemicals produce graded responses through dose dependent interactions with target tissues. Understanding the mode of action can elucidate key precursor steps, dose dependency, and human relevance of observed animal toxicity. With hazards and potential target tissues identified, physiologically based pharmacokinetic modeling helps refine dose response modeling, aids species extrapolation of internal dosimetry, and serves as a crucial aid in determining which internal measures of dose are most related to toxic outcome. Benchmark dose modeling surpasses the ‘traditional” NOAEL/LOAEL approach to dose response modeling, because this US EPA-recommended approach uses response data from the entire range of doses (and it also can be applied to internal dose metrics!) to identify a point of departure. Once response levels are identified in animals or in humans, the chemical specific adjustment factor approach provides a framework for inclusion of empirical toxicokinetic and dose response data to avoid reliance on default uncertainty factor values for inter- and intraspecies dose extrapolation. And, all of these approaches can be accomplished using freeware! To register, please visit the SOT Annual Meeting website. You may also access a full listing of the 2014 CE courses.