The National Academies hosted a two-day workshop entitled “Systems Biology—Informed Risk Assessment” at The Academies Building, June 14–15, 2012, and several SOT members participated as moderators or panelists. The National Academies hosted this event as 2012 marks the 5th anniversary of the report, “Toxicity Testing in the 21st Century.” SOT speakers included Kim Boekelheide, Robert Devlin, Dean Jones, Lauren Zeise, George Daston, Donna Mendrick, and Joyce Tsuji. The Emerging Science standing committee holds three to four meetings per year on the use of new discoveries, tools, and approaches for guiding environmental health decisions. These meetings provide a public venue for communication among government, industry, environmental groups, and the academic community. This National Research Council activity is sponsored by the National Institute of Environmental Health Sciences (NIEHS). NIEHS, located in Research Triangle Park, North Carolina, is one of 27 research institutes and centers that comprise the National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS). The mission of the NIEHS is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease.