Submitted by Kristen Ryan and Lynea Murphy, Chairpersons of 2017 CE AM03
The 2017 Continuing Education (CE) Course AM03 offers a refresher for guideline chronic toxicity/carcinogenicity testing of environmental chemicals: the old and the new. This SOT CE course, Current Principles for Nonclinical Chronic Toxicity/Carcinogenicity Testing of Environmental Chemicals, will provide the basic tools for this type of testing in rodents, which is considered the “gold-standard” approach for identifying potential hazards of chemicals and is necessary to inform risk assessment or risk management. This course is encouraged for toxicologists/scientists who work in regulated product development (e.g., chemical industries), scientists who may be responsible for monitoring or directing contracted chronic toxicity/carcinogenicity studies, as well as regulators of chemicals in commerce or environmental contaminants. Presenters from industry, government, and international agencies will outline core concepts for the assessment of chemical-related toxicity associated with chronic exposure while providing detailed examples that illustrate how these studies are used to evaluate potential risk(s) to humans.
The course will begin with an overview of the current practices for conducting chronic toxicity and carcinogenicity studies and provide examples for how integrated testing strategies may aid in refinement of study design/conduct. The next presentation of this course will focus on evaluating rodent pathology in chronic toxicity studies (i.e., what to expect and pathology peer review). Next, an overview of the regulatory requirements for chronic toxicity/carcinogenicity studies will be presented with a discussion of how data inform regulatory decisions with a focus on environmental chemicals. The final presentation in this course will highlight recent advances in identifying and classifying carcinogens, with an emphasis on the development and application of novel approaches and high throughput data streams in human health hazard assessments. For information on the full 2017 CE Program, visit the SOT website.