The National Academy of Sciences (NAS) plans to conduct a comprehensive review of the US Environmental Protection Agency’s (US EPA) Integrated Risk Information System (IRIS), which is designed to protect Americans’ health and the environment. In 2011, NAS issued a series of recommendations to improve the program, and US EPA has incorporated those recommendations. NAS plans to review current methods for weight of evidence analyses and recommend approaches for weighing scientific evidence for chemical hazard identification. For more information about IRIS go to, the US EPA's Integrated Risk Information System (IRIS) website.