Submitted by: Urmila Kodavanti and Juergen Pauluhn, 2014 CE Course Chairs
Toxicity-Based Inhalation Dosimetry is the Key Step to Epidemiological Dose-effect Analysis of Complex Atmospheres
Inhalation is the most important route of exposure for environmental and occupational pollutants, airborne pharmaceutical agents, nanomaterials, and naturally occurring products. They can elicit harmful effects in humans as a single substance or interactive chemistry within heterogeneous mixture and phases (e.g., vapor-aerosol interactions). The dynamics are ultimately complex and yet least understood as well as in terms of what this means to inhalation dosimetry within the diverse respiratory tract. Inhalation toxicologists and pharmacologists are faced with interpretation of toxicological findings from experimental animal models with laboratory-generated atmospheres. The associated exposure regime- and bioassay-specific outcomes have to be translated to differing exposure patterns and related adverse health in humans.
The only Continuing Education (CE) course on “Innovations in Methodologies for Inhalation Exposure and Interpretations of In Vivo Toxicity (PM10),” never before offered, provides one with the indepth knowledge of the technologies used for highly-controlled inhalational exposure x time relationships, including the facets of the physicochemistry of mixtures of evolving combustion by-products, nanomaterials, and atmospherically aged pollutants in relation to their toxicity. This course also bridges in vivo with in vitro technological innovations for exposing respiratory tract target cells at human-relevant concentrations in air liquid interphases. In addition, the course explains how the dosimetry-aspects of respiratory tract deposition and retention can judiciously be utilized to better understand nociceptive neurogenic, sensory responses versus direct effects in cellular systems leading to toxicity. This course will improve the understanding of how multiple exposure-related variables can be utilized to translate inhalation toxicity to human safety assessment of pharmaceuticals, chemical agents and nanoparticulates found in occupational and environmental settings.
For complete information about this Advanced CE course, including our speaker bios, we invite you to visit the SOT 2014 Annual Meetng website. At the meeting website, you can access a full listing of the CE courses and register to attend.