Hosted by the SOT Dermal Toxicology Specialty Section
First, we will introduce the DTSS Paper of the Year Winner by diving into the cutting-edge work of Nancy Hopf et al., who will deliver a game-changing analysis of phthalate absorption through the skin. By integrating in vitro diffusion studies with human biomonitoring, their study quantifies dermal absorption, metabolism, and elimination of three major phthalates: diethyl phthalate (DEP), dibutyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP). How much actually gets through our skin? This research redefines our understanding of exposure to these ubiquitous chemicals.
Second, we will explore new insights from Hans Raabe et al., winner of the Informa Healthcare Paper of the Year in Dermal Toxicology, challenging the reliability of traditional in vivo irritation tests like the Draize rabbit test. The study critically compares in vivo and in vitro methods for pesticide classification, exposing concerns about the predictivity of outdated animal models, particularly for mild to moderate irritants. With reproducibility rates under 50% for these classifications, these findings carry major implications for regulatory hazard assessments and the future of non-animal testing strategies.
Don't miss this opportunity to hear from leading experts reshaping how we understand dermal exposure and regulatory toxicology! Join us in congratulating their great accomplishments.
Speakers & Respective Publications:
Nancy Hopf, PhD, Unisanté, Center for Primary Care & Public Health, University of Lausanne, Switzerland
Hopf et al. (2024) “Human Skin Absorption of Three Phthalates” Toxicology Letters—Winner of the 2024 DTSS Annual Paper of the Year Award
Hans Raabe, MS, Institute for In Vitro Sciences, Gaithersburg, MD, USA
Raabe et al. (2024) “Human Relevance of In Vivo and In Vitro Skin Irritation for Hazard Classification of Pesticides” Cutaneous and Ocular Toxicology—Winner of the Informa Healthcare Paper of the Year in Dermal Toxicology
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