General Considerations of Using Non-Human Primate in Non-Clinical Ocular Drug Research

Hosted by: The SOT Ocular Toxicology Specialty Section

Registration required for this free webinar.

Non-human primate (NHP) is widely used in the non-clinical research of ocular drugs due to its unique anatomy and physiology. In this webinar, we will discuss the basic biology of the NHP eye compared to human and other species (rabbit and rodents) in anatomy and physiology, as well as the advantages and concerns of using the NHP eye in preclinical ocular research and drug discovery. We will share major background findings in ocular toxicity studies in different types of test articles (biologics and gene therapy) in different species. The origin and principle of immunogenicity in preclinical ocular studies will be discussed, along with representative images of ocular immunogenicity findings, and experience in risk mitigation strategies. We will introduce NHP ocular disease models, and present examples of using these models for efficacy studies with different routes of administration. We will also discuss the ophthalmic endpoints for ocular efficacy and toxicity studies, and present typical ocular findings related to the immune and test articles. Additionally, we will briefly discuss the differences in toxicological study practices in the US and China. Lastly, we will summarize our ocular study capabilities and experience at both sites, including efficacy and toxicology studies.

Speaker:

Eric (Wankun) Xie, MD, PhD, Director of Ophthalmology, JOINN Laboratories