Guide to High Throughput Toxicokinetic (HTTK) Parameters

Guide to High Throughput Toxicokinetic (HTTK) Parameters

Wednesday, February 12, 2025

3:00 PM to 4:30 PM (US EST, UTC -5)

Hosted by: The SOT Risk Assessment and Exposure Specialty Sections

Registration required for this free webinar.

HTTK mathematical models can provide predictions of absorption, distribution, metabolism, and excretion for chemicals without in vivo data. However, the models still require chemical-specific parameters to describe key aspects of toxicokinetics. Public repositories make in vitro measured toxicokinetic data available for more than 1000 chemicals. These data have further been used to train quantitative structure-property relationship (QSPR) models allowing predictions for novel chemicals without in vivo or in vitro data. This presentation will 1) review key parameters needed for HTTK, 2) summarize available in vitro and in silico means for attaining chemical-specific parameters, and 3) briefly report estimated confidence in predictions made with in vitro and QSPR-based HTTK predictions.

Speaker:

• John Wambaugh, PhD, US EPA

Registration required for this free webinar.