Non-SOT Event: Inside the Intrathecal Space and ICV Dosing: Practical Principles and Real-World Less

When:  Feb 25, 2026 from 11:30 AM to 01:00 PM (ET)
  • Intrathecal (IT) and intracerebroventricular (ICV) administration enable direct access to the central nervous system but introduce route-specific complexities in nonclinical study design, execution, and interpretation. This webinar translates those complexities into practical principles for toxicologists aiming to deliver sound risk assessment and regulatory-ready packages. The speakers will examine how administration parameters, surgical technique, catheter/device considerations, dosing paradigms, and species selection (rodent vs. nonrodent) shape data quality and translational relevance. Direct IT delivery can produce procedure-related microscopic findings from localized injury or irritation of CNS tissues; however, microscopic changes of similar character and/or severity may also arise from the test article (TA), complicating interpretation. Approaches that can be used to help differentiate procedure-related from TA-related microscopic changes will also be discussed.

    SPEAKERS:

    Technical Considerations for Intrathecal and Intracerebroventricular Routes: Essential Insights for Toxicologists–Stefania Cinquino, BSc

    Intrathecal Administration in Nonhuman Primates: Technique, Study Designs, Challenges–Florian Timo Ludwig, PhD

    Procedure-Related Microscopic Findings Secondary to Intrathecal Dosing of Test-Articles–Lisa Berman-Booty, VMD, PhD, DACVP

    There is no fee for joining the live webinar, but advance registration is required.
More information

Location

Online Instructions:
Url: https://aim-hq.zoom.us/webinar/register/WN_TXfsoA2LTtqEnHFQs5tuEQ
Login: There is no fee for joining the live webinar, but advance registration is required: https://aim-hq.zoom.us/webinar/register/WN_TXfsoA2LTtqEnHFQs5tuEQ