Rethinking Chemical Carcinogenicity Assessment in the Context of NAMs: Current Frameworks, State of the Science, and New Horizons
Hosted by the SOT Carcinogenesis Specialty Section and SOT Women in Toxicology Special Interest Group
Registration is required for this free webinar
Science is rapidly evolving for a better understanding of cancer disease pathophysiology upon chemical exposure. However, the need to maintain adequate protection of human health against cancer hazards remains. A critical component of regulatory toxicology is the assessment of adverse health effects, and thus risks, in humans exposed to chemicals.
Fast advancements in the development of New Approach Methodologies (NAMs) to assess systemic toxicity have led to an increased understanding of chemical carcinogenicity and to the possibility of replacing (or at least reducing and refining) vertebrate animal testing for future hazards evaluation.
Such advances in the understanding of chemically induced malignancy (e.g., role of the microenvironment, plasticity and biological pathways of transformation) along with the development of state-of-the-art technology (e.g., single cell and multi-omics, Next-Generation Sequencing, models of cellular transformation) provide an opportunity to modernize the evaluation of health risk from exposures to chemicals. Specifically, updated regulatory guidance (e.g., the 2022 S1B(R1) Addendum to S1B Testing for Carcinogenicity of Pharmaceuticals) allows for the use of existing information and for NAMs to be used as part of an integrative framework for risk assessment.
In this session, we are rethinking chemical carcinogenicity assessment, bringing together three women scientists working in basic research and risk evaluation from the US, Canada, and European Union. We will report about current frameworks and the state of the science in understanding and testing chemical carcinogenicity with NAMs and discuss new horizons in the field.
We all share the common goal of advancing regulatory guidance and tools for more efficacious cancer preventive strategies to protect human health.
Speakers:
Amber Goetz, PhD, Syngenta CP LLC
Carole Yauk, PhD, University of Ottawa, Canada
Annamaria Colacci, PhD, Università di Bologna, Italy