Using Defined Approaches (DAs) to Predict the Human Skin Sensitization Potential of Chemicals Previously Untested in NAMs
Registration is required for this free webinar
Hosted by the SOT Risk Assessment Specialty Section
Skin sensitization leading to allergic contact dermatitis is an important toxicological endpoint, which needs to be considered within a risk assessment for multiple chemical types across many different industries. There are several New Approach Methodologies (NAMs) that have been developed for this adverse outcome, including in silico models, in chemico assays and in vitro assays. These are vital tools for assessing sensitization potential without using animal studies, and they typically progress from scientific development through to adoption within OECD test guidelines over several years. However, none of the currently accepted NAMs for this endpoint is thought to be a sufficient 1:1 replacement for an animal test, and hence several defined approaches have been published in OECD guideline 497 which combine various NAMs to provide a better understanding of sensitization potential for use within chemical risk assessments.
One of the challenges when using NAMs and defined approaches is having a good understanding of both their performance and applicability domain within new areas of chemical space. This webinar will discuss a set of 22 chemicals which were chosen because they have both known human sensitization potential and do not have any published NAM data. Novel NAM data in three assays and two models have been generated for these chemicals, and the data was analyzed enabling lessons to be learnt about both the performance and applicability of the non-animal methods and defined approaches. Both general trends and specific case studies will be discussed, highlighting the key role that expert knowledge can play in understanding which assays and models are likely to be most appropriate for the chemical in question. It is hoped that the newly generated NAM data will prove useful to others in the field who are developing and validating defined approaches, ultimately improving the tools available to assess the risk of chemicals causing skin sensitization in humans.
Speakers:
Martyn Chilton, PhD, Lhasa Limited, United Kingdom
Darren Kidd, PhD, Scientific Specialist, Labcorp Early Development Laboratories