Hosted by: Inhalation and Respiratory Specialty Section
Registration required for this free webinar.
Rodent models are commonly used for studying pulmonary toxicity of chemicals/toxicants, initial screening of therapeutic efficacy, and toxicity profiling of new chemical entities (NCEs). However, testing NCEs in large animals that are close to humans in phylogeny and that share close similarities in anatomy and physiology with humans is generally recommended before initiating clinical trials. The US Food and Drug Administration (US FDA) has an animal rule to approve NCEs based on rodent and large animal models for therapeutic indications where clinical trials are not feasible due to ethical and safety concerns. Many investigators feel apprehensive of large animal models for obvious complexities in several aspects. In this seminar, strategies for the successful conduct of large animal pulmonary models will be discussed with emphasis on comparative animal models (key differences between rodent and non-rodent models, their advantages and limitations), animal model selection, key anatomical considerations, animal preparation and instrumentation, anesthetic regimen, mechanical ventilation, positional maneuvers, pulmonary function testing, bronchoscopy, imaging modalities, euthanasia, necropsy, sample collection, and data analysis.
Speaker:
Satya Achanta, DVM, PhD, DABT, Duke University School of Medicine
Registration required for this free webinar.