Dr. Hines earned his Ph.D. in biochemistry from the University of Texas Southwestern Medical School in 1980. Following his postdoctoral fellowship at the University of Vermont College of Medicine (1980-1983), he became Assistant Professor (1983-1988) and, later (1988-1989), Associate Professor at the Eppley Institute for Research in Cancer and Allied Diseases and the Department of Biochemistry at the University of Nebraska Medical Center. Dr. Hines was recruited to the Wayne State University School of Medicine as Associate Professor of Pharmacology and Pediatrics Associate and in 1995, was promoted to Professor of Pharmacology. In 1999, he assumed a position as Professor of Pediatrics and Pharmacology and Toxicology at the Medical College of Wisconsin where he also served as Associate Director of the Children’s Research Institute of the Children’s Hospital and Health Systems (2005-2012) and Co-Section Chief of Clinical Pharmacology, Pharmacogenetics, and Teratology in the Department of Pediatrics. In addition, Dr. Hines was Adjunct Professor of Biological Sciences at the University of Wisconsin-Milwaukee (2006-2012). In 2012, Dr. Hines accepted the position of Associate Director for Health at the National Health and Environmental Effects Research Laboratory in the Office of Research and Development of the U.S. Environmental Protection Agency. In this position, he managed the three NHEERL health divisions and their diverse research portfolio, as well as the Research Core Unit. He retired from the US Environmental Protection Agency in 2020. In 2021, Dr. Hines was appointed as Adjunct Professor in the Department of Environmental Health Sciences, Yale School of Public Health.
Dr. Hines approached research questions using a transdisciplinary tactic, assembling and leading research teams with expertise spanning from molecular biology and analytical chemistry to clinical cohort studies. Throughout his academic career, Dr. Hines’ research was supported by various organizations, including state health organizations, private foundations, industry contracts and the National Institutes of Health. He has over 150 publications focused on mechanisms whereby exposures to environmental toxicants or drugs alter gene regulation and the genetic/epigenetic basis for interindividual differences in response to exposures. Over the last 13 years of his academic career, his research turned to elucidating how and through what mechanisms the enzymes involved in toxicant and drug disposition change during early life stages and the interaction of genetic/epigenetic variation with this normal developmental process. The impact of this body of work is reflected by an h-index of 49 (Google Scholar, 2021), numerous invitations to present his research at both national and international meetings, invitations to serve on serval Federal and State advisory committees. He also has served as an Associate Editor or Editorial Board Member for nine peer-reviewed journals over his career and is currently a member of the Drug Metabolism and Disposition and Current Opinions in Toxicology Editorial Boards.
In addition to service on numerous committees and in component group leadership roles, Dr. Hines served as a Society of Toxicology Councilor from 2009-2010 and was elected to the Presidential Chain, in 2017, serving as President from May 1, 2019 through April 30, 2021.