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2021 Annual Meeting Report: Discussing New Models and Exposure Systems during the 2021 Respiratory Toxicology Poster Session

The year 2020 marked the spread of a global pandemic that took the world by surprise and halted life as we knew it. It also emphasized the dangers posed by air-borne pathogens and their potential to cause massive havoc. For a respiratory toxicologist, these were interesting times! Scientific...

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2021 Annual Meeting Report: Rebecca Fry Delivers Translational Impact Award Lecture

Dr. Rebecca Fry, a professor at the University of North Carolina at Chapel Hill, was awarded the 2021 SOT Translational Impact Award for her translational research on developmental toxicants and public health. Her Award Lecture during the 2021 SOT Annual Meeting and ToxExpo, “The Placenta: A...

Blog Entry
2021 Annual Meeting Report: The Future of Threshold of Toxicological Concern (TTC) in Next-Generation Risk Assessment

The threshold of toxicological concern (TTC) is a science-based concept that categorizes chemicals with low-level exposures. No appreciable human health risk for a lifetime of 70 years is expected for exposure values below the TTC. The US Food and Drug Administration (US FDA) Threshold of...

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2021 Annual Meeting Report: Fundamental Quantitative Principles for Improving Toxicological Science and Risk Assessment

Why do some toxicologists make inadequate propositions or assumptions while interpreting quantitative data? And why do these same mistakes occur repeatedly? It all comes down to violation of three fundamental quantitative principles. This was presented by Dr. Wout Slob, the recipient of the 2019...

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2021 Annual Meeting Report: Using the Placenta to Study Environmental Exposures

The placenta is a very unique organ, responsible for ensuring the healthy development of fetuses early in life. However, we still know very little about this organ despite its importance. During the 2021 SOT Annual Meeting and ToxExpo Symposium Session titled “Environmental Influences on...

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2021 Annual Meeting Report: Roll of the Splice: Understanding the Role of Alternative Splicing in Predictive Toxicology and Medicine

Alternative splicing events can lead to differential responses to xenobiotics because of the modified synthesis of proteins. In other words, how each new protein variant is able to contribute to metabolism and disease progression is a roll of the dice. In the Workshop Session “Revising Biology...

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2021 Annual Meeting Report: Future of Uncertainty Factors in In Vitro Studies

Uncertainty factors were developed in the 1980s by the US Environmental Protection Agency (US EPA) to derive a margin of safety of a chemical when the data are extrapolated from animals to humans. As we move toward animal-free testing with the application of new approach methods (NAMs), animal...

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2021 Annual Meeting Report: Approaches in Selection of Human-Relevant Doses from Nonclinical Toxicokinetic Data

“All substances are poisons; there is none which is not a poison. The right dose differentiates a poison.” –Paracelsus (AD 1493–1541) The first step in designing a successful nonclinical toxicity study is the selection of appropriate dose levels. Risk assessment of a drug or chemical involves...

Blog Entry
2021 Annual Meeting Report: An Introduction to High-Throughput Single Cell Assays for Toxicology

In an era of rapidly advancing technology, the learning curve required to incorporate new techniques into your research can be intimidating. The terminology alone can be a barrier to entry as you work through new protocols and read up on the available literature. Even as someone who uses single...

Blog Entry
2021 Annual Meeting Report: Artificial Intelligence in Toxicology

“If our era is the next Industrial Revolution, as many claim, AI is surely one of its driving forces.” –Fei-Fei Li 1 Artificial intelligence (AI) is surely the “driving force” in many areas of industrial application, but more so in the field of toxicology. This was more evident during one of...