ToxSci June 2024 Issue Available

By Cynthia Rider posted 05-30-2024 11:59 AM


The June 2024 issue of Toxicological Sciences includes a Distinguished Highlight that reviews particulate matter exposure, the resultant health effects, and the lack of understanding of the mechanisms that lead to systematic health effects. The issue also features a Contemporary Review that discusses advances in 3D pluripotent stem cell models that may assist in developmental toxicology research while a Systematic Review assesses the likelihood of a causal relationship between formaldehyde and lymphohematopoietic cancers. Additionally, in a Forum article, the Belgian Scientific Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) Committee provides a critical view on the working of REACH. Finally, a ToxSpotlight article describe a two-chamber liver-organ coculture model for use in determining toxicity on target tissues in the presence of physiologically relevant human liver metabolism, and a second ToxSpotlight examines inhalation exposure of plastic incineration emissions and resultant inflammation, oxidative stress, and impaired bioenergetics in primary human respiratory epithelial cells.


Other papers in the June 2024 issue (sorted by topic category) are:


Cytokeratin-18 Is a Sensitive Biomarker of Alanine Transaminase Increase in a Placebo-Controlled, Randomized, Crossover Trial of Therapeutic Paracetamol Dosing (PATH-BP Biomarker Substudy)(Open Access)

Developmental and Reproductive Toxicology

Ethynylestradiol Feminizes Gene Expression Partly in Testis Developing as Ovotestis and Disrupts Asymmetric Müllerian Duct Development by Eliminating Asymmetric Gene Expression in Japanese Quail Embryos

Environmental Toxicology

Inhalation of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated via Ahr Activation at the Air-Blood Interface

Organophosphate Ester Flame Retardants and Plasticizers Affect the Phenotype and Function of Hepg2 Liver Cells


The Aryl Hydrocarbon Receptor Differentially Modulates the Expression Profile of Antibody Isotypes in a Human B-Cell Line

Trichloroethylene Metabolite Modulates DNA Methylation-Dependent Gene Expression in Th1-Polarized CD4+ T Cells fom Autoimmune-Prone Mice

Molecular, Biochemical, and Systems Toxicology

Characterization of Individual Bile Acids In Vivo Utilizing a Novel Low Bile Acid Mouse Model

Organ Specific Toxicology

Repeated Exposure to Eucalyptus Wood Smoke Alters Pulmonary Gene and Metabolic Profiles in Male Long-Evans Rats

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