The June 2024 issue of Toxicological Sciences includes a Distinguished Highlight that reviews particulate matter exposure, the resultant health effects, and the lack of understanding of the mechanisms that lead to systematic health effects. The issue also features a Contemporary Review that discusses advances in 3D pluripotent stem cell models that may assist in developmental toxicology research while a Systematic Review assesses the likelihood of a causal relationship between formaldehyde and lymphohematopoietic cancers. Additionally, in a Forum article, the Belgian Scientific Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) Committee provides a critical view on the working of REACH. Finally, a ToxSpotlight article describe a two-chamber liver-organ coculture model for use in determining toxicity on target tissues in the presence of physiologically relevant human liver metabolism, and a second ToxSpotlight examines inhalation exposure of plastic incineration emissions and resultant inflammation, oxidative stress, and impaired bioenergetics in primary human respiratory epithelial cells.
Other papers in the June 2024 issue (sorted by topic category) are:
Biomarkers
“Cytokeratin-18 Is a Sensitive Biomarker of Alanine Transaminase Increase in a Placebo-Controlled, Randomized, Crossover Trial of Therapeutic Paracetamol Dosing (PATH-BP Biomarker Substudy)” (Open Access)
Developmental and Reproductive Toxicology
“Ethynylestradiol Feminizes Gene Expression Partly in Testis Developing as Ovotestis and Disrupts Asymmetric Müllerian Duct Development by Eliminating Asymmetric Gene Expression in Japanese Quail Embryos”
Environmental Toxicology
“Inhalation of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated via Ahr Activation at the Air-Blood Interface”
“Organophosphate Ester Flame Retardants and Plasticizers Affect the Phenotype and Function of Hepg2 Liver Cells”
Immunotoxicology
“The Aryl Hydrocarbon Receptor Differentially Modulates the Expression Profile of Antibody Isotypes in a Human B-Cell Line”
“Trichloroethylene Metabolite Modulates DNA Methylation-Dependent Gene Expression in Th1-Polarized CD4+ T Cells fom Autoimmune-Prone Mice”
Molecular, Biochemical, and Systems Toxicology
“Characterization of Individual Bile Acids In Vivo Utilizing a Novel Low Bile Acid Mouse Model”
Organ Specific Toxicology
“Repeated Exposure to Eucalyptus Wood Smoke Alters Pulmonary Gene and Metabolic Profiles in Male Long-Evans Rats”
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